Description

5'-o-(Dimethoxytrityl)-2-(Dimethylaminomethylidene-Amino)-6-(Methoxylamino)Purine-2'-Deoxyriboside is a sophisticated, protected nucleoside derivative essential for oligonucleotide synthesis. This high-purity building block is critical for ensuring the fidelity and efficiency of solid-phase phosphoramidite chemistry. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of therapeutic nucleic acids, diagnostic probes, and advanced genetic research tools.

Application

• Oligonucleotide Synthesis: Serves as a key phosphoramidite precursor for the automated synthesis of DNA and RNA strands.
• Antisense & siRNA Therapeutics: Used in the research and production of antisense oligonucleotides and small interfering RNA (siRNA) for targeted gene silencing.
• Diagnostic Probe Development: Enables the creation of highly specific labeled probes for PCR, FISH, and microarray technologies.
• Pharmaceutical R&D: Acts as a critical raw material in the discovery and preclinical development of nucleic acid-based drugs.
• Academic Research: Supports fundamental studies in molecular biology, genetics, and biochemistry requiring custom oligonucleotides.
• Aptamer Production: Facilitates the synthesis of DNA libraries for SELEX processes to identify novel aptamers.

Basic Information

Product Name	5'-o-(Dimethoxytrityl)-2-(Dimethylaminomethylidene-Amino)-6-(Methoxylamino)Purine-2'-Deoxyriboside
CAS No.	136986-36-2
Molecular Formula	C35H39N7O6
Molecular Weight	653.73 g/mol
Synonyms	5'-O-DMT-2-(Dimethylaminomethylideneamino)-6-(methoxylamino)purine-2'-deoxyriboside; 2'-Deoxy-5'-O-(4,4'-dimethoxytrityl)-N2-(dimethylaminomethylene)-6-(methoxyamino)purine Riboside; DMT-dP(OMe) Amidite precursor; N2-(Dimethylaminomethylene)-6-(methoxyamino)-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)purine; Protected 2-Amino-6-methoxyaminopurine Deoxyriboside
EINECS	Contact for details

Quality Control

Our production of this high-value nucleoside derivative adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for sensitive synthesis workflows. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.