Description

5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-N-[6((1,4 CAS NO 135887-12-6 is a sophisticated, high-purity nucleoside derivative used as a critical building block in advanced chemical synthesis. This compound matters because it provides a protected intermediate essential for the precise construction of oligonucleotides and other complex biomolecules. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, diagnostic probes, and genetic research materials.

Application

• Oligonucleotide Synthesis: Serves as a key phosphoramidite precursor in solid-phase synthesis for research-scale and therapeutic oligonucleotide production.
• Antisense & siRNA Development: Used in the research and manufacturing of antisense oligonucleotides and small interfering RNA (siRNA) candidates for gene silencing applications.
• Diagnostic Probe Manufacture: A vital component in creating labeled probes for genetic testing, fluorescence in situ hybridization (FISH), and other molecular diagnostic tools.
• Pharmaceutical Intermediate: Acts as a protected nucleoside intermediate in the multi-step synthesis of nucleoside-based antiviral or anticancer drug candidates.
• Bioconjugation & Labeling: Utilized in chemical biology for site-specific modification of biomolecules due to its reactive functional groups.
• Academic & Industrial R&D: Employed in chemical and biochemical research laboratories for studying nucleic acid chemistry and developing new synthetic methodologies.

Basic Information

Product Name	5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-N-[6((1,4 CAS NO 135887-12-6
CAS No.	135887-12-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	5'-DMT-2'-deoxy-N-[6((1,4; DMT-protected deoxynucleoside derivative; 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxy-N-[6((1,4; Nucleoside phosphoramidite precursor; MMTr-protected nucleoside; 5'-O-[Bis(p-methoxyphenyl)phenylmethyl] derivative; Protected 2'-deoxynucleoside
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. We adhere to strict in-process controls and final release specifications, with testing typically including HPLC for purity, NMR for structural confirmation, and mass spectrometry to guarantee identity and quality suitable for sensitive synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., argon or nitrogen) after opening to prevent degradation. Long-term storage at -20°C is recommended for optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.