Description

4-(tert-Butyldimethylsiloxy)Butylmagnesium Chloride, 0.50 M In Thf is a high-purity, organometallic Grignard reagent solution essential for advanced synthetic chemistry. This compound matters for its role as a key building block in the precise introduction of the protected 4-hydroxybutyl moiety into complex molecular frameworks. Pharmaceutical, agrochemical, and advanced materials researchers need it for constructing active pharmaceutical ingredients (APIs), specialty polymers, and liquid crystals. Its standardized 0.50 M concentration in THF ensures consistent, reproducible results in critical coupling and chain-extension reactions.

Application

• Pharmaceutical Intermediate Synthesis: A crucial reagent for constructing side chains and molecular scaffolds in Active Pharmaceutical Ingredients (APIs), particularly in oncology and CNS drug candidates.
• Agrochemical Manufacturing: Used in the synthesis of advanced herbicides and fungicides, where the protected hydroxyl functionality is required for selective bioactivity.
• Liquid Crystal & OLED Material Production: Serves as a key precursor for synthesizing alkoxysilane derivatives used in display technologies and organic light-emitting diodes.
• Polymer & Specialty Chemical Modification: Enables the functionalization of polymers and surfaces with siloxy-protected terminal groups for enhanced properties.
• Cross-Coupling Reactions: Employed in Kumada and related cross-coupling methodologies to form new carbon-carbon bonds in complex molecule assembly.
• Academic & Process R&D: A valuable tool for research chemists developing novel synthetic pathways and scaling up laboratory processes to pilot plant production.

Basic Information

Product Name	4-(tert-Butyldimethylsiloxy)Butylmagnesium Chloride, 0.50 M In Thf
CAS No.	134588-97-9
Molecular Formula	C10H23ClMgOSi
Molecular Weight	246.94 g/mol
Synonyms	4-(TBDMS-oxy)butylmagnesium chloride; 4-(tert-Butyldimethylsilyloxy)butylmagnesium chloride; (4-(tert-Butyldimethylsilanyloxy)butyl)magnesium chloride; TBDMSO-(CH2)4MgCl; Grignard Reagent TBDMS-O-C4-MgCl; 4-(tert-Butyldimethylsilyloxy)-1-butylmagnesium chloride; 4-(Tert-butyldimethylsiloxy)butylmagnesium chloride solution
EINECS	Contact for details

Quality Control

Every batch of our 4-(tert-Butyldimethylsiloxy)Butylmagnesium Chloride solution is manufactured and analyzed under strict quality protocols to ensure it meets the high standards required for sensitive organometallic chemistry. We employ quantitative titration (Karl Fischer for water, GC for solvent) and spectroscopic methods to guarantee consistent concentration, purity, and reactivity. A comprehensive Certificate of Analysis (COA) detailing assay, impurity profile, and solvent content is provided with each shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in the original sealed bottle under a dry, inert atmosphere (argon or nitrogen) in a cool, well-ventilated area. This solution is highly volatile, easily oxidized, and moisture-sensitive. Recommended storage temperature is 2°C to 8°C. Protect from all light exposure and sources of ignition. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow solution
Concentration	0.50 M in Tetrahydrofuran (THF)
Assay (by Titration)	0.48 M - 0.52 M
Water Content (Karl Fischer)	< 50 ppm
Identification (IR/NMR)	Conforms to structure

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.