Description

3,4,5-Trimethoxyphenylmagnesium Bromide Solution 0.5M In Tetrahydrofuran is a versatile organometallic reagent, specifically a Grignard reagent, widely used in synthetic organic chemistry for the formation of carbon-carbon bonds. Its primary value lies in enabling the efficient and selective introduction of the 3,4,5-trimethoxyphenyl moiety into complex molecular architectures. This compound is particularly critical for research and development chemists in the pharmaceutical and agrochemical industries, where it serves as a key building block for the synthesis of active pharmaceutical ingredients (APIs), fine chemicals, and advanced materials.

Application

• Pharmaceutical Intermediate Synthesis: A crucial building block for constructing complex molecules, particularly in the development of new drug candidates and active pharmaceutical ingredients (APIs).
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and plant growth regulators that incorporate the trimethoxyphenyl functional group.
• Fine Chemical & Specialty Material Production: Employed in the manufacture of advanced organic materials, liquid crystals, and dyes where precise molecular structure is required.
• Academic & Industrial R&D: Serves as a fundamental reagent in laboratory-scale organic synthesis for method development and exploratory chemistry.
• Nucleophilic Aromatic Substitution & Addition Reactions: Reacts with a wide range of electrophiles including carbonyl compounds (aldehydes, ketones, esters), epoxides, and carbon dioxide.

Basic Information

Product Name	3,4,5-Trimethoxyphenylmagnesium Bromide Solution 0.5M In Tetrahydrofuran
CAS No.	133095-91-7
Molecular Formula	C9H11BrMgO3 (in THF)
Molecular Weight	~247.39 g/mol (for C9H11BrMgO3)
Synonyms	Magnesium, bromo(3,4,5-trimethoxyphenyl)-; (3,4,5-Trimethoxyphenyl)magnesium bromide; 3,4,5-Trimethoxybenzene magnesium bromide; Grignard reagent, 3,4,5-trimethoxyphenylMgBr; 3,4,5-Trimethoxyphenyl magnesium bromide solution; 3,4,5-TMPMgBr; TMPhMgBr; 3,4,5-Trimethoxybenzylmagnesium bromide (common misnomer)
EINECS	Contact for details

Quality Control

Our 3,4,5-Trimethoxyphenylmagnesium Bromide Solution is manufactured under strict quality-controlled conditions to ensure batch-to-batch consistency and reliability for critical synthetic applications. Each lot undergoes rigorous analytical testing, including titration for Grignard concentration and impurity profiling. Certificates of Analysis (COA) detailing concentration, solvent content, and relevant specifications are provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C (refrigerated) to maintain stability and prevent degradation. This solution is moisture-sensitive and easily oxidized; ensure containers are properly sealed and purged after each use. Keep away from heat, sparks, open flames, and incompatible materials such as acids, water, and oxidizing agents.

Specification

Item	Specification
Appearance	Clear, colorless to light yellow solution
Concentration	0.5 M in Tetrahydrofuran (THF)
Assay (Titration)	0.45 - 0.55 M
Identification (IR)	Conforms to structure
Water Content (KF)	< 100 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.