Description

Adenyl-(3',5')-2'-Deoxyfluoroguanylyl-(3',5')-Adenosine is a chemically modified dinucleotide, specifically a fluorinated analog of a natural RNA building block. This compound is of significant value in nucleic acid research and therapeutic development due to its ability to modulate stability and biological activity. It is primarily required by pharmaceutical R&D teams, biotechnology companies, and academic research institutions focused on antisense oligonucleotides, siRNA, and novel therapeutic modalities.

Application

• Antisense Oligonucleotide (ASO) Synthesis: Used as a modified building block to enhance nuclease resistance and target binding affinity.
• Small Interfering RNA (siRNA) Development: Incorporated to improve pharmacokinetic properties and therapeutic efficacy of RNAi-based drugs.
• Structural Biology Studies: Employed in NMR and X-ray crystallography to investigate nucleic acid-protein interactions and conformational dynamics.
• Diagnostic Probe Design: Serves as a component in high-specificity probes for detecting genetic sequences.
• Medicinal Chemistry Research: A key intermediate for exploring structure-activity relationships (SAR) in nucleoside-based drug discovery.
• Biochemical Tool Development: Used in enzymatic assays to study the mechanisms of polymerases, nucleases, and helicases.

Basic Information

Item	Details
Product Name	Adenyl-(3',5')-2'-Deoxyfluoroguanylyl-(3',5')-Adenosine
CAS No.	131889-16-2
Molecular Formula	C20H23FN10O11P2
Molecular Weight	660.40 g/mol
Synonyms	2'-Deoxy-2'-fluoroguanylyl-(3'→5')-adenosine; d(FG)-A; Apa-dF-Gua; Fluorinated Dinucleotide; 2'-F-G-A Dinucleotide; Adenosine 5'-[P1-(2'-deoxy-2'-fluoroguanosine 5')-P2-(adenosine 5')] diphosphate; 5'-O-[Hydroxy({hydroxy[hydroxy(3-{3-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(6-oxo-1H-purin-9-yl)oxolan-2-yl]propanamido}propoxy)phosphoryl}oxy)phosphoryl]-2'-deoxy-2'-fluoroguanosine
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and pharmaceutical applications. Each batch is characterized using advanced analytical techniques including HPLC, MS, and NMR to confirm identity, purity, and structural integrity. Certificates of Analysis (COA) detailing all specifications are available upon request, supporting your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.