Description

9-(2-Deoxy-5-o-Triphospho-β-Ribofuranosyl)-N(6),N(6)-Ethano-2,6-Diaminopurine is a chemically modified nucleoside triphosphate analog designed for advanced biochemical research and therapeutic development. This compound is critical for applications requiring stable, non-hydrolyzable nucleotide mimics to study enzyme mechanisms and signal transduction pathways. It is primarily utilized by pharmaceutical researchers, diagnostic developers, and academic institutions focused on nucleotide-based drug discovery and molecular biology.

Application

• Biochemical Research: As a non-hydrolyzable ATP analog for studying kinase and ATPase enzyme kinetics, inhibition, and structure-function relationships.
• Pharmaceutical Development: A key intermediate or tool compound in the research and development of nucleotide-based therapeutics targeting viral infections and cancers.
• Diagnostic Assays: Used in the development of high-sensitivity enzymatic assays and diagnostic kits that require stable nucleotide cofactors.
• Molecular Biology: Serves as a substrate analog in studies of DNA/RNA polymerases and other nucleic acid-metabolizing enzymes to elucidate replication and repair mechanisms.
• Signal Transduction Studies: Employed to investigate purinergic signaling pathways and the role of nucleotide-binding proteins in cellular regulation.

Basic Information

Product Name	9-(2-Deoxy-5-o-Triphospho-β-Ribofuranosyl)-N(6),N(6)-Ethano-2,6-Diaminopurine
CAS No.	130699-78-4
Molecular Formula	C₁₄H₂₂N₆O₁₂P₃
Molecular Weight	607.28 g/mol
Synonyms	N6,N6-Ethano-2,6-diaminopurine 2'-deoxyriboside 5'-triphosphate; 2'-Deoxy-N6,N6-ethanoadenosine 5'-triphosphate; dEATP; 2'-Deoxy-N6,N6-ethano-2,6-diaminopurine riboside triphosphate; Non-hydrolyzable ATP analog; 1,N6-Etheno-2'-deoxyadenosine-5'-triphosphate analog; dATP-ε; dN6,N6-Etheno-2'-deoxyadenosine-5'-triphosphate
EINECS	Contact for details

Quality Control

Our production of this high-purity biochemical adheres to stringent quality protocols. Every batch is characterized and tested to ensure identity, purity, and stability, with comprehensive analysis via HPLC, NMR, and MS. A Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment, supporting research under GLP and cGMP frameworks where required.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, keep under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay (UV)	≥ 90%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in water, buffer solutions

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.