Description

4-Fluorophenylmagnesium Chloride is a versatile organometallic reagent, specifically a Grignard reagent, widely used in organic synthesis for the formation of carbon-carbon bonds. Its value lies in its ability to introduce the 4-fluorophenyl moiety into target molecules, a key structural feature in advanced pharmaceutical and agrochemical intermediates. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries seeking to synthesize complex fluorinated aromatic compounds.

Application

• Pharmaceutical Intermediate Synthesis: Key building block for creating active pharmaceutical ingredients (APIs) containing fluorinated aromatic rings, enhancing metabolic stability and bioavailability.
• Agrochemical Manufacturing: Used in the synthesis of herbicides, fungicides, and insecticides where the 4-fluorophenyl group contributes to biological activity.
• Liquid Crystal & OLED Material Production: Serves as a precursor in the synthesis of fluorinated organic semiconductors and liquid crystal compounds for electronic displays.
• Cross-Coupling Reactions: Employed in palladium-catalyzed reactions (e.g., Kumada coupling) to form biaryl structures common in many functional materials.
• Nucleophilic Addition Reactions: Reacts with carbonyl compounds (aldehydes, ketones, esters) to produce secondary and tertiary alcohols with fluorinated aromatic side chains.
• Polymer Chemistry: Acts as an initiator or monomer functionalization agent in the development of specialty fluorinated polymers.

Basic Information

Item	Detail
Product Name	4-Fluorophenylmagnesium Chloride
CAS No.	130387-74-5
Molecular Formula	C6H4FMgCl
Molecular Weight	154.85 g/mol
Synonyms	p-Fluorophenylmagnesium Chloride; (4-Fluorophenyl)magnesium Chloride; 1-Fluoro-4-(chloromagnesio)benzene; Magnesium, chloro(4-fluorophenyl)-; Grignard Reagent (4-Fluorophenyl); 4-Fluorophenyl MgCl; 4-FC6H4MgCl
EINECS	Contact for details

Quality Control

Our 4-Fluorophenylmagnesium Chloride is manufactured under stringent quality control protocols to ensure batch-to-batch consistency and high reactivity. We provide comprehensive Certificates of Analysis (COA) for each lot, detailing key parameters such as concentration (typically supplied as a solution in THF or diethyl ether), assay, and impurity profile. Our quality system is designed to meet the rigorous standards required for cGMP and ISO-guided applications in fine chemical synthesis.

Storage

Preserve in a tightly closed container, protected from light. This material is hygroscopic (moisture-sensitive) and easily oxidized; it must be stored under an inert atmosphere (argon or nitrogen) in a cool, dry place. For solutions, store at 2-8°C. Keep away from heat, sparks, open flames, and strong oxidizers. Use only in a well-ventilated area or under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to light brown solution
Concentration (in THF)	0.5 M - 2.0 M (Custom concentrations available)
Assay (Titration)	≥ 95%
Identification (IR)	Conforms to structure
Water Content (KF)	< 500 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.