Description

Guanosine 5'-(Trihydrogen Diphosphate)-n-(4-Azidophenyl)-2-Phosphoramido-3-(4-Hydroxy-3-Iodophenyl)Propionamide Monoanhydride is a sophisticated, high-purity nucleotide derivative designed for advanced biochemical research and development. This compound is critical for applications requiring precise molecular labeling and cross-linking, particularly in the study of nucleic acid-protein interactions and enzyme mechanisms. It is primarily utilized by research institutions, pharmaceutical R&D departments, and diagnostic kit manufacturers focused on probe development, affinity labeling, and targeted drug discovery.

Application

• Photoaffinity Labeling Probes: Acts as a critical reagent for cross-linking and identifying binding sites of proteins, enzymes, and receptors that interact with guanosine-based structures.
• Biochemical Research: Used in mechanistic studies of nucleotide-binding enzymes, including kinases, polymerases, and GTPases, to elucidate catalytic pathways and inhibition.
• Diagnostic Assay Development: Serves as a key component in the synthesis of labeled probes for sensitive detection systems, such as ELISA and blotting techniques.
• Structural Biology: Employed in X-ray crystallography and NMR studies to investigate the three-dimensional structure and dynamics of nucleotide-binding domains.
• Drug Discovery Platforms: Integral to high-throughput screening (HTS) assays and fragment-based drug design targeting purinergic signaling pathways.
• Antiviral & Anticancer Research: Investigated for its potential as a modified nucleoside precursor in the development of novel therapeutic agents.

Basic Information

Product Name	Guanosine 5'-(Trihydrogen Diphosphate)-n-(4-Azidophenyl)-2-Phosphoramido-3-(4-Hydroxy-3-Iodophenyl)Propionamide Monoanhydride
CAS No.	129592-79-6
Molecular Formula	C25H25IN8O12P3
Molecular Weight	873.33 g/mol
Synonyms	Guanosine 5'-diphosphate, 2'-(4-azidophenyl)phosphoramido-3'-(4-hydroxy-3-iodophenyl)propionamide monoanhydride; 8-Azido-GDP derivative; N-(4-Azidophenyl)-P2-(guanosine-5'-) P1-{3-[4-hydroxy-3-iodophenyl]propionamido} triphosphate; Photoactivatable GDP analog; 2'-(4-Azidobenzamido)-3'-(4-hydroxy-3-iodobenzoyl) GDP; GTP photoaffinity label derivative; 129592-79-6
EINECS	Contact for details

Quality Control

Our production of this nucleotide analog adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This compound is strictly light-sensitive and hygroscopic. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. For long-term stability, store under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.