Description

4-tert-Butylbenzylmagnesium Bromide is a highly reactive organometallic reagent, specifically a Grignard reagent, widely used in organic synthesis. Its primary value lies in its ability to act as a powerful nucleophile and strong base, facilitating the formation of new carbon-carbon bonds. This makes it an essential intermediate for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, enabling the synthesis of complex molecules and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly those requiring the introduction of a tert-butylbenzyl moiety.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and pesticides where its specific aromatic structure imparts desired biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and transition metal complexes.
• Fine Chemical Production: Employed in the manufacture of dyes, pigments, and specialty polymers that benefit from its aromatic and bulky tert-butyl group.
• Material Science Research: Utilized in the synthesis of organic semiconductors, liquid crystals, and other advanced organic electronic materials.
• Cross-Coupling Reactions: Acts as a crucial reagent in Kumada and other transition-metal-catalyzed cross-coupling reactions to form biaryl and other complex structures.

Basic Information

Product Name	4-tert-Butylbenzylmagnesium Bromide
CAS No.	127349-68-2
Molecular Formula	C11H15BrMg
Molecular Weight	251.44 g/mol
Synonyms	(4-(tert-Butyl)phenyl)methylmagnesium Bromide; 1-(tert-Butyl)-4-(bromomagnesio)methylbenzene; p-tert-Butylbenzylmagnesium Bromide; 4-tert-Butylbenzyl Magnesium Bromide; 4-tert-Butylbenzylmagnesium Bromide Solution; (4-tert-Butylbenzyl)magnesium Bromide; Grignard Reagent (4-tert-Butylbenzyl)
EINECS	Contact for details

Quality Control

Our 4-tert-Butylbenzylmagnesium Bromide is produced under stringent quality protocols to ensure batch-to-batch consistency and reliability for critical synthetic applications. Each lot undergoes comprehensive analysis, including titration for concentration and purity assessment. A Certificate of Analysis (COA) detailing specific results is provided with every shipment to support your quality assurance and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly reactive and moisture-sensitive nature, this product must be stored under an inert atmosphere (argon or nitrogen) at recommended temperatures, typically between 2°C and 8°C for solutions. The storage area should be cool, dry, and well-ventilated, away from incompatible materials such as acids, oxidizers, and moisture sources.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Concentration (in THF or Ether)	0.5 M - 2.0 M (Customizable)
Assay (by Titration)	≥ 95%
Identification (IR/NMR)	Conforms to structure

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.