Description

6-(5-o-(Dimethoxytrityl)-β-D-2-Deoxyribrofuranosyl)-3,4-Dihydro-8H-Pyrimido[4,5-C][1,2]Oxazin-7-One is a sophisticated nucleoside derivative and a critical building block in advanced oligonucleotide synthesis. This high-purity intermediate is essential for the production of modified DNA and RNA sequences, enabling groundbreaking research and therapeutic development. It is primarily required by pharmaceutical R&D teams, biotechnology companies, and specialized CROs/CMOs engaged in antisense therapy, siRNA, and diagnostic probe development.

Application

• Oligonucleotide Synthesis: A key phosphoramidite precursor for the solid-phase synthesis of modified DNA and RNA strands.
• Antisense & siRNA Therapeutics: Used in the manufacture of therapeutic oligonucleotides designed for targeted gene silencing and regulation.
• Diagnostic Probe Development: Incorporation into fluorescent or chemically-labeled probes for advanced molecular diagnostics and hybridization assays.
• Research & Development: Serves as a vital reagent in academic and industrial labs for studying nucleic acid structure, function, and interactions.
• Pharmaceutical Intermediates: Acts as a high-value intermediate in the cGMP-compliant production of novel nucleic acid-based drugs.
• Bioconjugation: Provides a reactive handle for the site-specific conjugation of drugs, labels, or delivery agents to oligonucleotides.

Basic Information

Product Name	6-(5-o-(Dimethoxytrityl)-β-D-2-Deoxyribrofuranosyl)-3,4-Dihydro-8H-Pyrimido[4,5-C][1,2]Oxazin-7-One
CAS No.	126128-43-6
Molecular Formula	C₃₄H₃₅N₃O₇
Molecular Weight	597.66 g/mol
Synonyms	6-[5-O-(4,4'-Dimethoxytrityl)-β-D-2-deoxyribofuranosyl]-3,4-dihydro-8H-pyrimido[4,5-c][1,2]oxazin-7-one; DMT-dPyr-Oxazinone; 5'-O-DMT-2'-deoxyribosyl-pyrimido-oxazinone; Nucleoside Oxazinone Derivative; DMT-protected Oxazinone Nucleoside; 2'-Deoxyribofuranosyl Pyrimidooxazinone DMT Ester; Advanced Nucleic Acid Monomer; Contact for EINECS details.

Quality Control

Our production of this high-value nucleoside intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and purity suitable for sensitive oligonucleotide synthesis. Quality is verified through comprehensive analytical methods including HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each batch, confirming identity, purity, and absence of critical impurities. We support development under GMP-like conditions for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.