Description

Lc-Smcc CAS NO 125559-00-4 is a specialized heterobifunctional crosslinking agent widely used in bioconjugation and protein chemistry. This compound is essential for creating stable, site-specific linkages between biomolecules, enabling advanced research and development in life sciences. It is particularly valuable for pharmaceutical companies, diagnostic kit manufacturers, and academic research institutions engaged in antibody-drug conjugate (ADC) development, protein immobilization, and assay development.

Application

• Antibody-Drug Conjugate (ADC) Linker: A key reagent for covalently attaching cytotoxic payloads to monoclonal antibodies, forming stable ADCs for targeted cancer therapies.
• Protein-Protein Conjugation: Facilitates the crosslinking of different proteins or peptides to create novel multifunctional biomolecules for research and therapeutic applications.
• Protein Immobilization: Used to tether proteins onto solid surfaces, such as sensor chips, microplates, or chromatography resins, for biosensing, diagnostic assays, and affinity purification.
• Biomolecule Labeling: Enables the attachment of various probes (e.g., fluorophores, biotin, enzymes) to proteins, antibodies, or other biomolecules without compromising their biological activity.
• Nanoparticle Functionalization: Serves as a bridge to conjugate targeting ligands (like antibodies or peptides) to the surface of nanoparticles for targeted drug delivery and imaging.
• Stable Intermediate Synthesis: Acts as a critical building block in the multi-step synthesis of more complex crosslinkers and bioconjugation tools.

Basic Information

Product Name	Lc-Smcc
CAS No.	125559-00-4
Molecular Formula	C20H24N2O8
Molecular Weight	420.42 g/mol
Synonyms	SMCC-PEG4; LC-SMCC (Long Chain SMCC); Succinimidyl-[(N-maleimidopropionamido)-tetraethyleneglycol] ester; Maleimide-PEG4-NHS ester; SMCC-Polyethylene Glycol; NHS-PEG4-Maleimide; 4-(N-Maleimidomethyl)cyclohexanecarboxylic acid N-hydroxysuccinimide ester PEG derivative; N-(ε-Maleimidocaproyloxy)succinimide ester polyethylene glycol conjugate
EINECS	Contact for details

Quality Control

Our Lc-Smcc is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for sensitive bioconjugation applications. Certificates of Analysis (COA) with detailed specifications are provided with every shipment to guarantee traceability, consistency, and reliability for your critical research and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Solubility	Soluble in DMSO, DMF, acetonitrile
Water Content (KF)	≤ 1.0%
Functional Group Activity	≥ 90% (NHS ester & Maleimide)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.