Description

P(3)-1-(2-Nitro)Phenylethylguanosine 5'-o-Triphosphate is a chemically modified nucleotide triphosphate analog, specifically designed for advanced biochemical research and diagnostic applications. Its core value lies in its ability to act as a substrate or inhibitor for specific enzymes, enabling precise studies in molecular biology and the development of sensitive detection assays. This high-purity compound is essential for researchers and developers in the fields of pharmaceutical discovery, molecular diagnostics, and enzymology who require reliable and well-characterized biochemical tools.

Application

• Enzyme Kinetics & Mechanism Studies: Used as a substrate analog to investigate the catalytic mechanisms of polymerases, kinases, and other nucleotide-processing enzymes.
• Diagnostic Assay Development: Serves as a key component in the development of novel diagnostic kits, particularly for detecting specific enzymatic activities or for signal amplification.
• Nucleic Acid Labeling & Sequencing: Employed in specialized protocols for labeling DNA or RNA probes, or in next-generation sequencing technologies that utilize modified nucleotides.
• Pharmaceutical Research: Acts as a potential lead compound or tool for studying nucleotide-based drug targets and screening for enzyme inhibitors.
• Biochemical Tool Manufacturing: Supplied as a critical raw material for companies producing high-value reagent kits for life science research.

Basic Information

Product Name	P(3)-1-(2-Nitro)Phenylethylguanosine 5'-o-Triphosphate
CAS No.	124830-99-5
Molecular Formula	C18H22N7O17P3
Molecular Weight	701.33 g/mol
Synonyms	1-(2-Nitrophenyl)ethyl-guanosine-5'-triphosphate; 2-Nitrobenzyl-caged GTP; NPE-caged GTP; (2-Nitrophenyl)ethyl-caged Guanosine Triphosphate; P3-1-(2-Nitrophenyl)ethyl-GTP; Caged GTP, (2-Nitrophenyl)ethyl-; 5'-O-[(2-Nitrophenyl)ethyl]guanosine triphosphate; Photolabile GTP analog
EINECS	Contact for details

Quality Control

Every batch of P(3)-1-(2-Nitro)Phenylethylguanosine 5'-o-Triphosphate is manufactured under strict quality control protocols to ensure the highest standards of purity and consistency required for research. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS analysis, to confirm identity, purity, and the absence of critical impurities like unmodified nucleotides. Certificates of Analysis (COA) with detailed chromatographic data are available upon request for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, it is recommended to store desiccated under an inert atmosphere. Allow the product to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.