Description

2',3'-Dideoxyinosine-[2',3'-3H] is a tritium-labeled nucleoside analog, a critical tool compound for advanced biochemical and pharmacological research. This radiolabeled derivative is essential for conducting high-sensitivity metabolic and pharmacokinetic studies, enabling precise tracking and quantification. It is primarily utilized by research scientists and pharmaceutical developers in drug discovery, particularly for investigating antiviral mechanisms, nucleotide metabolism, and nucleic acid biochemistry.

Application

• Metabolic Pathway Tracing: Used as a radiolabeled tracer to study the cellular uptake, distribution, and metabolic fate of dideoxyinosine and related analogs.
• Antiviral Research: Critical for mechanistic studies of nucleoside reverse transcriptase inhibitors (NRTIs) in HIV and other viral infection models.
• Pharmacokinetics (PK) & Absorption, Distribution, Metabolism, and Excretion (ADME): Enables sensitive quantification in biological matrices for determining drug bioavailability, half-life, and clearance.
• Enzyme Kinetics Assays: Serves as a substrate for studying the activity and inhibition of key enzymes like nucleoside kinases and polymerases.
• Autoradiography & Imaging: Facilitates the visualization of drug localization in tissues and cells for target engagement studies.
• Biochemical Synthesis: Acts as a labeled building block for the synthesis of more complex radiolabeled nucleotides or oligonucleotides.

Basic Information

Product Name	2',3'-Dideoxyinosine-[2',3'-3H]
CAS No.	124516-24-1
Molecular Formula	C10H113HN4O3
Molecular Weight	~254.2 g/mol (for unlabeled form)
Synonyms	2',3'-Dideoxyinosine-tritiated; [2',3'-3H]ddI; Tritiated Dideoxyinosine; 2',3'-Dideoxy-[2',3'-3H]inosine; 9-[(2R,5S)-5-(Hydroxymethyl)oxolan-2-yl]-3H-purin-6-one-tritiated; ddI-[2',3'-3H]; NSC 612049-tritiated; Didanosine-tritiated analog
EINECS	Contact for details

Quality Control

Every batch of 2',3'-Dideoxyinosine-[2',3'-3H] is manufactured and analyzed under controlled conditions to ensure high radiochemical purity and specific activity. Quality is verified through analytical techniques including HPLC with radiometric detection. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing specific activity, radiochemical purity, chemical purity, and solvent composition. Our quality system supports research requiring reliable and consistent radiolabeled compounds.

Storage

Preserve in a tightly closed container, protected from light. Store at or below -20°C in the original solvent as specified on the label and COA. For long-term storage, keep at -70°C to minimize radiolytic decomposition. Always handle in accordance with local radiation safety regulations.

Specification

Item	Specification
Appearance	Clear colorless to slightly yellow solution
Specific Activity	10-40 Ci/mmol (Contact for exact value)
Radiochemical Purity	≥ 95% (by HPLC)
Chemical Purity	≥ 90% (by HPLC, UV detection)
Identification	Co-elutes with reference standard (HPLC)
Solvent	Ethanol:Water or custom (as specified)
Concentration	1 mCi/mL (Nominal)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.