Description

5'-O-(4,4'-Dimethoxytrityl)-N6-Phenoxyacetyl Adenosine is a high-purity, protected nucleoside derivative essential for solid-phase oligonucleotide synthesis. This compound serves as a critical phosphoramidite building block, enabling the precise and automated assembly of DNA and RNA sequences. It is primarily required by biotechnology, pharmaceutical, and diagnostic research sectors for applications in antisense therapy, siRNA development, and molecular diagnostics.

Application

• Oligonucleotide Synthesis: Key monomer for the automated solid-phase synthesis of DNA and RNA strands.
• Antisense & siRNA Therapeutics: Production of modified oligonucleotides for gene silencing and therapeutic applications.
• Diagnostic Probe Development: Manufacture of labeled probes for PCR, sequencing, and microarray technologies.
• Research & Development: Fundamental building block in academic and industrial labs for nucleic acid chemistry.
• Synthesis of Modified Nucleosides: Intermediate for creating nucleoside analogs with tailored properties.

Basic Information

Product Name	5'-O-(4,4'-Dimethoxytrityl)-N6-Phenoxyacetyl Adenosine
CAS No.	121076-16-2
Molecular Formula	C39H37N5O8
Molecular Weight	703.75 g/mol
Synonyms	DMTr-Pac-Adenosine; N6-Phenoxyacetyl-5'-O-(4,4'-dimethoxytrityl)adenosine; 5'-O-DMT-N6-Pac-adenosine; Adenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-N-[2-(phenoxyacetyl)]-; 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxy-N6-phenoxyacetyladenosine (common misnomer); DMT-A(Pac); Protected Adenosine Phosphoramidite Precursor
EINECS	Contact for details

Quality Control

Our 5'-O-(4,4'-Dimethoxytrityl)-N6-Phenoxyacetyl Adenosine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive oligonucleotide synthesis. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and moisture content. We adhere to cGMP guidelines where applicable to support our clients' regulatory requirements in therapeutic and diagnostic development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in acetonitrile, DMF, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.