Description

Ac-Rc Phosphoramidite CAS NO 121058-88-6 is a high-purity, specialized phosphoramidite monomer, a critical building block in the automated synthesis of oligonucleotides. Its precise chemical structure ensures efficient and reliable coupling, which is paramount for producing high-quality DNA and RNA sequences. This product is essential for research institutions, diagnostic developers, and pharmaceutical companies engaged in genomics, molecular diagnostics, and therapeutic oligonucleotide development.

Application

• Oligonucleotide Synthesis: A key monomer for the solid-phase synthesis of DNA and RNA strands on automated synthesizers.
• Therapeutic Oligonucleotide Production: Used in the manufacture of antisense oligonucleotides, siRNA, and aptamers for pharmaceutical applications.
• Diagnostic Probe Development: Essential for creating labeled probes for PCR, microarrays, and fluorescence in situ hybridization (FISH).
• Research & Development: Serves as a fundamental reagent in academic and industrial labs for genomics and molecular biology research.
• Synthesis of Modified Oligonucleotides: Enables the incorporation of specific functional groups or labels into synthetic nucleic acids.
• Next-Generation Sequencing (NGS): Used in the preparation of custom primers and adapters for various sequencing platforms.

Basic Information

Product Name	Ac-Rc Phosphoramidite
CAS No.	121058-88-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Acetyl-Rc Phosphoramidite; 5'-O-(4,4'-Dimethoxytrityl)-N2-acetyl-2'-deoxyguanosine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; dG(ac) Phosphoramidite; N2-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyguanosine-3'-(2-cyanoethyl N,N-diisopropylphosphoramidite); Ac-dG Phosphoramidite
EINECS	Contact for details

Quality Control

Our Ac-Rc Phosphoramidite is manufactured under strict quality systems to ensure batch-to-batch consistency and high performance in sensitive oligonucleotide synthesis. Each lot undergoes rigorous analytical testing, including HPLC purity analysis and 31P NMR spectroscopy, to confirm identity and meet stringent purity specifications. Certificates of Analysis (COA) detailing all quality parameters are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (argon or nitrogen) in a dry, moisture-free environment. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity.

Specification

Item	Specification
Appearance	White to off-white solid or foam
Identification (HPLC)	Conforms to reference standard
Identification (31P NMR)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.