Description

2-Fluorobenzylmagnesium Chloride is a versatile organometallic reagent, specifically a Grignard reagent, widely used in synthetic organic chemistry. Its primary value lies in its ability to introduce the 2-fluorobenzyl group into target molecules, enabling the construction of complex fluorinated intermediates. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries who require reliable, high-purity building blocks for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate Synthesis: A key building block for creating active pharmaceutical ingredients (APIs) and drug candidates containing the 2-fluorobenzyl moiety.
• Agrochemical Development: Used in the synthesis of novel herbicides, fungicides, and pesticides where fluorination enhances biological activity and stability.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized ligands and organometallic catalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the development of fluorinated polymers, liquid crystals, and organic electronic materials to modify physical properties.
• Custom Fluorination Chemistry: Enables precise carbon-fluorine bond formation in complex molecules for structure-activity relationship (SAR) studies.
• Scale-up Process Chemistry: Suitable for kilogram-scale production in controlled manufacturing environments for commercial product development.

Basic Information

Product Name	2-Fluorobenzylmagnesium Chloride
CAS No.	120608-58-4
Molecular Formula	C7H6ClFMg
Molecular Weight	168.87 g/mol
Synonyms	2-Fluorobenzylmagnesium Chloride; (2-Fluorophenyl)methylmagnesium Chloride; Magnesium, Chloro(2-fluorophenyl)methyl-; o-Fluorobenzylmagnesium Chloride; 2-Fluorobenzyl Grignard Reagent; Grignard Reagent, 2-Fluorobenzylmagnesium Chloride; (2-Fluorobenzyl)magnesium Chloride; α-Fluoro-o-tolylmagnesium Chloride
EINECS	Contact for details

Quality Control

Our 2-Fluorobenzylmagnesium Chloride is manufactured under stringent quality control protocols to ensure batch-to-batch consistency and high reactivity. Each lot is analyzed to confirm concentration (typically supplied as a solution in THF or diethyl ether), purity, and the absence of deleterious impurities. A comprehensive Certificate of Analysis (COA) detailing assay results, titration data, and solvent content is provided with every shipment. Our quality management system supports cGMP and ISO standards for traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. This product is hygroscopic (moisture-sensitive) and must be stored under an inert atmosphere (argon or nitrogen) to prevent decomposition. For solutions, store at 2-8°C in a cool, dry, well-ventilated area away from incompatible materials such as acids, oxidizers, and moisture. Keep the container sealed when not in use.

Specification

Item	Specification
Appearance (Solution)	Clear, colorless to light yellow
Concentration	0.5 M to 2.0 M in THF or Et2O (Custom)
Assay (Titration)	≥ 95%
Identification (IR/NMR)	Conforms to structure
Water Content (KF)	≤ 100 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.