Description

5'-O-Dimethoxytrityl-N2-(N,N-Dimethylaminomethylene)-8-Aza-7-Deaza-2'-Deoxyguanosine is a high-purity, protected nucleoside phosphoramidite precursor, essential for the solid-phase synthesis of oligonucleotides. Its core value lies in enabling the precise incorporation of modified bases, which is critical for developing advanced research tools and therapeutic nucleic acids. This compound is primarily needed by biotechnology and pharmaceutical companies engaged in antisense therapy, siRNA development, diagnostic probe manufacturing, and fundamental genomic research.

Application

• Solid-Phase Oligonucleotide Synthesis: As a key phosphoramidite building block for automated DNA/RNA synthesizers.
• Antisense Oligonucleotide (ASO) Development: For creating modified oligonucleotides with enhanced nuclease resistance and binding affinity for therapeutic applications.
• siRNA and miRNA Synthesis: Enables the production of chemically modified small interfering RNAs to improve stability and efficacy in gene silencing.
• Diagnostic Probe Manufacturing: Used in the synthesis of labeled probes for PCR, FISH, and microarray technologies.
• Fundamental Biochemical Research: A vital reagent for studying nucleic acid structure, function, and protein interactions.
• Aptamer Development: For creating libraries of modified nucleic acid aptamers with specific target-binding properties.

Basic Information

Product Name	5'-O-Dimethoxytrityl-N2-(N,N-Dimethylaminomethylene)-8-Aza-7-Deaza-2'-Deoxyguanosine
CAS No.	118907-74-7
Molecular Formula	C37H41N7O6
Molecular Weight	679.77 g/mol
Synonyms	8-Aza-7-deaza-2'-deoxyguanosine, DMT-protected; 5'-O-(4,4'-Dimethoxytrityl)-N2-[(dimethylamino)methylene]-8-aza-7-deaza-2'-deoxyguanosine; DMTr-dG(8aza7deaza)amidite precursor; N2-(N,N-Dimethylaminomethylene)-5'-O-(4,4'-dimethoxytrityl)-8-aza-7-deaza-2'-deoxyguanosine; 8-Aza-7-deaza-dG DMT amidite; c7dG DMT amidite; 7-Deaza-8-aza-2'-deoxyguanosine derivative
EINECS	Contact for details

Quality Control

Our 5'-O-Dimethoxytrityl-N2-(N,N-Dimethylaminomethylene)-8-Aza-7-Deaza-2'-Deoxyguanosine is manufactured under strict quality systems to ensure batch-to-batch consistency for critical oligonucleotide synthesis. Each lot undergoes comprehensive analytical testing, including HPLC purity analysis, NMR spectroscopy for structural confirmation, and mass spectrometry. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Solubility	Soluble in acetonitrile, DMF, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.