Description

Octathymidylate-9-Aminoellipticine is a specialized synthetic oligonucleotide-alkaloid conjugate, representing a significant advancement in targeted molecular research. This compound is engineered to combine the sequence-specific binding properties of an octathymidylate chain with the potent biological activity of the 9-aminoellipticine moiety. It is primarily utilized by research institutions and pharmaceutical developers engaged in advanced studies of gene regulation, antisense therapeutics, and the mechanisms of topoisomerase II inhibition. The precise molecular architecture of this conjugate makes it a critical tool for probing nucleic acid interactions and developing novel therapeutic strategies.

Application

• Antisense Oligonucleotide Research: Serves as a model compound for studying the binding affinity, stability, and cellular uptake of sequence-specific antisense agents.
• Topoisomerase II Inhibition Studies: Used to investigate the mechanism of action and potency of ellipticine derivatives when tethered to a DNA sequence, providing insights into targeted chemotherapy.
• Molecular Probe Development: Acts as a foundational scaffold for creating fluorescent or radiolabeled probes to visualize and quantify specific DNA sequences in diagnostic assays.
• Structure-Activity Relationship (SAR) Analysis: Essential for pharmaceutical R&D to understand how the conjugation of oligonucleotides affects the pharmacological profile of ellipticine analogs.
• Gene Expression Modulation: Employed in preclinical research to evaluate the potential for targeted gene silencing or modulation via sequence-specific delivery of an active agent.

Basic Information

Item	Detail
Product Name	Octathymidylate-9-Aminoellipticine
CAS No.	117153-31-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	9-Aminoellipticine-octathymidylate Conjugate; d(T)8-9-Aminoellipticine; Oligothymidylate-9-Aminoellipticine; 9-AE-Oligo(dT)8; CAS 117153-31-8; 9-Aminoellipticine-linked Octathymidylic Acid; Antisense-Ellipticine Hybrid Compound
EINECS	Contact for details

Quality Control

Every batch of Octathymidylate-9-Aminoellipticine is produced and analyzed under stringent quality management protocols. Our products undergo rigorous purity and identity testing, including chromatographic and spectroscopic methods, to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and identification results is provided with each shipment to guarantee traceability and support your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed in a desiccated environment to prevent degradation. For long-term stability, consider storage at -20°C under inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Assay (UV-Vis)	≥ 90%
Water Content (KF)	≤ 5.0%
Oligonucleotide Length Verification (HPLC/Gel)	Confirms octamer sequence

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.