Description

2',6'-Dimethylcarbonylphenyl 9-Acridinecarboxylate 4'-Nhs Ester is a specialized, high-purity chemical building block designed for advanced bioconjugation and labeling applications. This compound matters as a critical reagent for researchers and manufacturers requiring precise covalent attachment of acridine-based fluorophores or functional groups to biomolecules like proteins, peptides, and oligonucleotides. It is primarily needed by professionals in pharmaceutical R&D, diagnostic assay development, and life science research for creating targeted probes, sensors, and therapeutic conjugates.

Application

• Bioconjugation Reagent: For the covalent labeling of antibodies, proteins, and peptides with acridine derivatives for fluorescence-based assays.
• Diagnostic Probe Synthesis: A key intermediate in manufacturing fluorescent probes and tags used in immunoassays (ELISA, lateral flow) and histochemistry.
• Pharmaceutical Research: Used in the development of drug-antibody conjugates (ADCs) and other targeted therapeutic agents where an acridine moiety is required.
• Nucleic Acid Labeling: Enables the tagging of oligonucleotides for fluorescence in situ hybridization (FISH) and other genomic detection techniques.
• Sensor Development: Acts as a precursor for creating chemical sensors and biosensors that rely on acridine's photophysical properties.
• Material Science Functionalization: Used to introduce reactive NHS ester groups onto surfaces or polymers for subsequent biomolecule immobilization.

Basic Information

Product Name	2',6'-Dimethylcarbonylphenyl 9-Acridinecarboxylate 4'-Nhs Ester
CAS No.	115853-72-0
Molecular Formula	C26H18N2O6
Molecular Weight	454.43 g/mol
Synonyms	9-Acridinecarboxylic acid, 2',6'-bis(methoxycarbonyl)[1,1'-biphenyl]-4-yl ester, N-hydroxysuccinimide ester; 4'-(N-Succinimidyloxycarbonyl)-2',6'-dimethoxycarbonylbiphenyl-4-yl 9-acridinecarboxylate; 2',6'-Dimethoxycarbonylbiphenyl-4-yl 9-acridinecarboxylate 4'-NHS Ester; Biphenyl-4-acridine NHS Ester; Acridine NHS Ester Derivative; Acridine Active Ester; Labeling Reagent 115853-72-0
EINECS	Contact for details

Quality Control

Our 2',6'-Dimethylcarbonylphenyl 9-Acridinecarboxylate 4'-Nhs Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and mass spectrometry, to ensure it meets the high standards required for sensitive research and diagnostic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.