Description

N6-Benzoyl-2'-Deoxy-5'-o-Dmt-A-Adenosine is a key, high-purity nucleoside phosphoramidite derivative used in the chemical synthesis of oligonucleotides. This compound is critical for ensuring high coupling efficiency and sequence fidelity in automated solid-phase DNA/RNA synthesis. It is an essential raw material for research institutions, diagnostic kit manufacturers, and pharmaceutical companies developing antisense oligonucleotides, siRNAs, and other therapeutic nucleic acids.

Application

• Oligonucleotide Synthesis: As a protected adenosine (A) building block (phosphoramidite) for automated solid-phase synthesis of DNA and RNA strands.
• Therapeutic Nucleic Acid Development: Production of antisense oligonucleotides (ASOs), small interfering RNAs (siRNAs), and aptamers for drug discovery and development.
• Diagnostic Probe Manufacturing: Synthesis of labeled probes and primers used in PCR, qPCR, sequencing, and microarray technologies.
• Research Grade Chemicals: Used in academic and industrial R&D for studying nucleic acid structure, function, and for creating custom oligonucleotide libraries.
• GMP-grade Production: Serves as a starting material for the synthesis of active pharmaceutical ingredients (APIs) in GMP-compliant manufacturing of oligonucleotide therapeutics.

Basic Information

Product Name	N6-Benzoyl-2'-Deoxy-5'-o-Dmt-A-Adenosine
CAS No.	112805-99-9
Molecular Formula	C38H35N5O7
Molecular Weight	673.72 g/mol
Synonyms	5'-O-(4,4'-Dimethoxytrityl)-N6-benzoyl-2'-deoxyadenosine; dA(Bz) Phosphoramidite Precursor; N6-Benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)adenosine; DMTr-dA(Bz)-OH; 2'-Deoxy-5'-O-(4,4'-dimethoxytrityl)-N6-benzoyladenosine; Protected Deoxyadenosine; Adenosine, N6-benzoyl-2'-deoxy-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-
EINECS	Contact for details

Quality Control

Our N6-Benzoyl-2'-Deoxy-5'-o-Dmt-A-Adenosine is manufactured under strict quality control protocols to ensure it meets the stringent purity requirements for oligonucleotide synthesis. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and moisture content. We adhere to ISO 9001 quality management standards, and material can be supplied under GMP guidelines for advanced therapeutic applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or CoA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere (e.g., nitrogen or argon) to maintain stability and prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in acetonitrile, DMF, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.