Description

3-(4,4'-Dimethoxytrityl)Propandiol-1-N,n-Diisopropyl (β-Cyanoethyl) Phosphoramidite is a high-purity phosphoramidite monomer, a critical building block in the automated solid-phase synthesis of oligonucleotides. This compound is essential for the controlled, stepwise addition of nucleosides, enabling the production of DNA and RNA strands with precise sequences. It is a key raw material for researchers and manufacturers in the fields of therapeutics, diagnostics, and genetic research, where reliable synthesis of high-quality oligonucleotides is paramount.

Application

• Oligonucleotide Synthesis: As a phosphoramidite monomer for the automated synthesis of DNA and RNA sequences.
• Therapeutic Development: Production of antisense oligonucleotides (ASOs), siRNA, and aptamers for targeted drug discovery.
• Diagnostic Probe Manufacturing: Creation of labeled probes for PCR, microarrays, and fluorescence in situ hybridization (FISH).
• Genetic Research: Synthesis of primers, linkers, and gene fragments for molecular biology applications.
• Bioconjugation: Serving as a precursor for the synthesis of modified oligonucleotides with functional groups for labeling or attachment.
• Academic & Industrial R&D: Fundamental research in genomics, synthetic biology, and nucleic acid chemistry.

Basic Information

Product Name	3-(4,4'-Dimethoxytrityl)Propandiol-1-N,n-Diisopropyl (β-Cyanoethyl) Phosphoramidite
CAS No.	110894-23-0
Molecular Formula	C34H45N2O6P
Molecular Weight	608.71 g/mol
Synonyms	DMT-Propanediol Phosphoramidite; 1,3-Propanediol, 1-[[bis(1-methylethyl)amino][2-cyanoethoxy]phosphino]-3-[bis(4-methoxyphenyl)phenylmethoxy]-, (R)-; 3-(4,4'-Dimethoxytrityloxy)propyl N,N-diisopropylamino cyanoethyl phosphoramidite; DMT-C3 Phosphoramidite; Spacer Phosphoramidite C3; 3'-DMT-Propyl Spacer Phosphoramidite; Propanediol Spacer CE Phosphoramidite
EINECS	Contact for details

Quality Control

Our 3-(4,4'-Dimethoxytrityl)Propandiol-1-N,n-Diisopropyl (β-Cyanoethyl) Phosphoramidite is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for sensitive oligonucleotide synthesis. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and moisture content. We adhere to industry best practices and can support requirements for use in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (argon or nitrogen) due to its hygroscopic and moisture-sensitive nature. Allow the sealed container to reach ambient temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid or foam
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.