Description

2-Chloro-2'-Deoxyadenosine Triphosphate is a modified nucleotide triphosphate analog crucial for advanced biochemical research and diagnostic development. Its core value lies in its ability to act as a chain terminator or substrate analog in enzymatic studies, particularly for DNA polymerases and reverse transcriptases. This compound is essential for researchers and manufacturers in pharmaceutical R&D, molecular diagnostics, and enzymology who require high-purity, reliable biochemical tools.

Application

• Enzymology Research: Used as a substrate or inhibitor in studies of DNA polymerases, reverse transcriptases, and other nucleotide-processing enzymes to understand mechanism and kinetics.
• Next-Generation Sequencing (NGS): Serves as a specialized nucleotide for developing novel sequencing chemistries and diagnostic assays.
• Antiviral Drug Development: Investigated as a potential chain-terminating analog in the research of nucleoside reverse transcriptase inhibitors (NRTIs).
• Molecular Biology Kits: A key component in the formulation of specialized kits for DNA labeling, mutagenesis, and PCR-based applications.
• Biochemical Probe Synthesis: Utilized in the synthesis of labeled probes for studying nucleic acid interactions and enzyme activities.
• Diagnostic Assay Development: Incorporated into proprietary assays for the detection of specific pathogens or genetic markers.

Basic Information

Product Name	2-Chloro-2'-Deoxyadenosine Triphosphate
CAS No.	106867-30-5
Molecular Formula	C10H15ClN5O12P3
Molecular Weight	549.62 g/mol
Synonyms	2-Cl-dATP; 2-Chloro-2'-deoxyadenosine-5'-triphosphate; 2-Chloro-2'-deoxyadenosine 5'-(tetrahydrogen triphosphate); Chlorodeoxyadenosine triphosphate; 2-Cl-2'-dATP; 2-Chloro-dATP; 2-Chloro-2'-deoxy-ATP; (2R,3S,5R)-5-(6-Amino-2-chloro-9H-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-yl trihydrogen triphosphate
EINECS	Contact for details

Quality Control

Our 2-Chloro-2'-Deoxyadenosine Triphosphate is manufactured under stringent controls to ensure the high purity and consistency required for sensitive research applications. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, MS). Certificates of Analysis (COA) detailing all specifications are provided to guarantee traceability and compliance with your research or GMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry atmosphere before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 3.0%
Solubility	Soluble in water or buffer solutions

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.