Description

5-(3-((3-(Methylthio)Propionyl)Amino)-1-Propenyl)-2'-Deoxyuridine-5'-Triphosphate is a modified nucleoside triphosphate analog, a critical building block for advanced biochemical research and diagnostics. Its core value lies in its ability to be incorporated into nucleic acid chains, enabling applications in molecular labeling, sequencing, and probe development. This high-purity biochemical is essential for researchers and manufacturers in the fields of molecular biology, diagnostic assay development, and pharmaceutical research.

Application

• Molecular Biology Research: Used as a substrate for DNA polymerases in enzymatic synthesis, PCR, and primer extension assays.
• Diagnostic Probe Development: Enables the synthesis of labeled DNA probes for sensitive detection in hybridization-based diagnostic kits (e.g., FISH, microarrays).
• Next-Generation Sequencing (NGS): Serves as a modified nucleotide for specialized sequencing-by-synthesis platforms requiring unique termination or detection properties.
• Bioconjugation & Labeling: The reactive functional group allows for site-specific conjugation to reporter molecules like fluorophores or haptens.
• Antiviral & Anticancer Research: Investigated as a potential prodrug or chain terminator in the development of novel therapeutic agents targeting viral or cellular polymerases.
• Enzymology Studies: A tool compound for studying the kinetics and specificity of DNA polymerases and other nucleotide-processing enzymes.

Basic Information

Product Name	5-(3-((3-(Methylthio)Propionyl)Amino)-1-Propenyl)-2'-Deoxyuridine-5'-Triphosphate
CAS No.	106542-91-0
Molecular Formula	C17H25N4O15P3S
Molecular Weight	650.39 g/mol
Synonyms	5-[3-[[3-(Methylthio)-1-oxopropyl]amino]-1-propen-1-yl]-2'-deoxyuridine 5'-(trihydrogen triphosphate); dUTP-(3-(Methylthio)propionyl)Amino-Propenyl derivative; Modified dUTP triphosphate; Allylamino dUTP analog; Thioether-modified nucleotide; 5-Substituted deoxyuridine triphosphate; N3-modified dUTP
EINECS	Contact for details

Quality Control

Our 5-(3-((3-(Methylthio)Propionyl)Amino)-1-Propenyl)-2'-Deoxyuridine-5'-Triphosphate is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for sensitive research applications. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a non-frost-free freezer. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation and storage under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Biological Activity	Incorporation by DNA polymerase confirmed

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.