Description

5,6-Dihydrothymidine 5'-Triphosphate (CAS NO 106094-51-3) is a chemically modified nucleotide triphosphate analog, serving as a critical building block and research tool in advanced molecular biology and biochemistry. Its primary value lies in its ability to act as a chain terminator or substrate analog in enzymatic studies, particularly for DNA polymerases and reverse transcriptases. This compound is essential for researchers and manufacturers in the fields of antiviral drug discovery, nucleic acid diagnostics, and enzymology, where precise control over nucleic acid synthesis is required.

Application

• Antiviral Drug Development: Used as a substrate analog in the study and inhibition of viral polymerases (e.g., HIV-1 reverse transcriptase) for the development of nucleoside reverse transcriptase inhibitors (NRTIs).
• Enzymology Research: Serves as a critical tool for investigating the kinetics, fidelity, and mechanism of DNA polymerases and other nucleotide-utilizing enzymes.
• Next-Generation Sequencing (NGS): Potential application as a modified nucleotide for specialized sequencing chemistries that require controlled termination or incorporation.
• Molecular Diagnostics: Can be utilized in the development of probe-based assays and diagnostic kits that require specific nucleotide analogs.
• Biochemical Reagent: A key component in specialized reagent kits for in vitro transcription, PCR, and other nucleic acid amplification techniques.
• Academic & Pharmaceutical R&D: Fundamental research into DNA replication, repair, and the biochemical basis of genetic diseases.

Basic Information

Product Name	5,6-Dihydrothymidine 5'-Triphosphate
CAS No.	106094-51-3
Molecular Formula	C10H17N2O14P3
Molecular Weight	482.16 g/mol
Synonyms	dTTP analog; 5,6-Dihydro-dTTP; 2'-Deoxy-5,6-dihydrothymidine 5'-triphosphate; 5,6-Dihydrothymidine triphosphate; DH-dTTP; 5,6-Dihydro-2'-deoxythymidine-5'-triphosphate; Modified nucleotide triphosphate; Chain-terminating nucleotide
EINECS	Contact for details

Quality Control

Our 5,6-Dihydrothymidine 5'-Triphosphate is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the exacting standards required for life science research and development. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to store desiccated at -20°C. Allow the vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Conforms
Purity (HPLC)	≥ 95%
Water Content (Karl Fischer)	≤ 5.0%
Solubility	Soluble in water or buffer solutions

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.