Description

7-Methyl-2μ-Deoxyguanosine 5μ-Triphosphate Sodium Salt is a chemically modified nucleotide triphosphate analog, a critical reagent for advanced molecular biology and biochemical research. This compound is essential for studying DNA damage, repair mechanisms, and enzymatic processes involving modified DNA substrates. It is primarily utilized by research institutions, diagnostic developers, and pharmaceutical companies engaged in epigenetics, oncology research, and the development of novel therapeutic agents.

Application

• Enzymatic Substrate for DNA Polymerases: Used as a modified nucleotide substrate in in vitro DNA synthesis and PCR-based assays to study incorporation fidelity and mutagenesis.
• Biochemical Research on DNA Damage & Repair: A vital tool for investigating the biological consequences and repair pathways of alkylated DNA lesions, such as those induced by environmental carcinogens.
• Synthesis of Modified Oligonucleotides: Enables the enzymatic incorporation of 7-methyl-2'-deoxyguanosine into oligonucleotides for structural, biophysical, and functional studies.
• Development of Diagnostic Assays: Serves as a key component in the development of sensitive assays for detecting DNA adducts and understanding their role in disease etiology.
• Pharmaceutical R&D: Used in high-throughput screening and mechanistic studies for drug candidates targeting DNA repair enzymes like alkyltransferases.

Basic Information

Product Name	7-Methyl-2μ-Deoxyguanosine 5μ-Triphosphate Sodium Salt
CAS No.	104809-10-1
Molecular Formula	C11H17N5O13P3Na2 (or similar, based on sodium salt form)
Molecular Weight	Contact for details
Synonyms	7-Methyl-dGTP Sodium Salt; 7-Methyl-2'-deoxyguanosine-5'-triphosphate trisodium salt; 7-Me-dGTP; m7dGTP; 2'-Deoxy-7-methylguanosine-5'-triphosphate sodium salt; 7-Methyl-2'-deoxy-GTP; 7-Methyl-deoxyguanosine triphosphate
EINECS	Contact for details

Quality Control

Our 7-Methyl-2μ-Deoxyguanosine 5μ-Triphosphate Sodium Salt is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the stringent requirements of research applications. Certificates of Analysis (COA) detailing purity, impurity profile, and concentration are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, desiccate at -20°C. Aliquot to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5%
Biological Activity	Suitable for enzymatic incorporation

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.