Description

(7S)-7β-[(3-Amino-2,3,6-Trideoxy-α-L-Arabino-Hexopyranosyl)Oxy]-9-Ethyl-7,8,9,10-Tetrahydro-6,9β,11-Trihydroxy-5,12-Naphthacenedione is a complex, high-purity anthracycline derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical intermediate or reference standard for the synthesis and analysis of novel therapeutic agents, particularly in oncology. It is essential for research institutions, pharmaceutical manufacturers, and fine chemical suppliers focused on developing next-generation cancer treatments and conducting rigorous analytical studies.

Application

• Pharmaceutical Intermediate: A key building block in the synthetic pathways for novel anthracycline-based chemotherapeutic agents.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control (QC/QA) of related active pharmaceutical ingredients (APIs).
• Biochemical Research: Employed in studies investigating the structure-activity relationships (SAR), mechanism of action, and metabolic pathways of anthracycline compounds.
• Preclinical Development: Serves as a starting material or standard in the early-stage discovery and development of new drug candidates targeting DNA intercalation and topoisomerase inhibition.
• Academic Research: Utilized by universities and research institutes for chemical synthesis projects and pharmacological studies.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.

Basic Information

Product Name	(7S)-7β-[(3-Amino-2,3,6-Trideoxy-α-L-Arabino-Hexopyranosyl)Oxy]-9-Ethyl-7,8,9,10-Tetrahydro-6,9β,11-Trihydroxy-5,12-Naphthacenedione
CAS No.	103476-98-8
Molecular Formula	C25H31NO9
Molecular Weight	489.52 g/mol
Synonyms	9-Ethyl-7,8,9,10-tetrahydro-6,9,11-trihydroxy-5,12-naphthacenedione, 7-[(3-amino-2,3,6-trideoxy-α-L-arabino-hexopyranosyl)oxy]-, (7S)-; 7-O-(3-Amino-2,3,6-trideoxy-α-L-arabino-hexopyranosyl)-9-ethyl-7,8,9,10-tetrahydro-6,9,11-trihydroxy-5,12-naphthacenedione; 9-Ethyl-7,8,9,10-tetrahydro-6,9,11-trihydroxy-5,12-naphthacenedione 7-(3-amino-2,3,6-trideoxy-α-L-arabino-hexopyranoside); Anthracycline derivative intermediate; Related to Menogaril synthesis.
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to stringent quality protocols suitable for pharmaceutical research and development. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We employ advanced analytical techniques including HPLC, NMR, and Mass Spectrometry to ensure batch-to-batch consistency and identity confirmation. Specifications can be aligned with client requirements for research-grade or cGMP-grade materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and opened under controlled conditions to minimize exposure to atmospheric moisture and light.

Specification

Item	Specification
Appearance	Orange to red-brown powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 2.0%; Total impurities ≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.