Description

Guanosine 5'-Tetraphosphate Tris Salt is a high-purity nucleotide derivative essential for biochemical research and pharmaceutical development. This compound serves as a critical substrate and regulator in enzymatic studies, particularly those involving nucleotide metabolism and signaling pathways. It is primarily utilized by research institutions, diagnostic manufacturers, and biotechnology companies for applications in molecular biology, enzymology, and the development of novel therapeutic agents.

Application

• Enzymatic Research: As a substrate for kinases, polymerases, and other nucleotide-dependent enzymes to study reaction mechanisms and kinetics.
• Molecular Biology: In the synthesis and study of oligonucleotides and complex nucleotide analogs for genetic research.
• Cell Signaling Studies: Investigation of intracellular signaling cascades where guanosine polyphosphates act as secondary messengers.
• Diagnostic Reagent Manufacturing: A key component in the formulation of assay kits for measuring enzyme activity or nucleotide concentrations.
• Pharmaceutical Development: Used in the research and development of drugs targeting nucleotide-binding proteins and metabolic pathways.
• Biochemical Standards: Serves as a high-purity reference standard for analytical method development and quality control in related industries.

Basic Information

Product Name	Guanosine 5'-Tetraphosphate Tris Salt
CAS No.	103213-27-0
Molecular Formula	C10H19N5O20P4 • xC4H11NO3
Molecular Weight	Contact for details
Synonyms	Guanosine-5'-tetraphosphate tris(tris(hydroxymethyl)aminomethane) salt; Gp4G Tris salt; Guanosine 5'-tetraphosphate, Tris salt; P1,P4-Bis(5'-guanosyl) tetraphosphate Tris salt; G5'pppp5'G Tris salt; GppppG Tris salt; Tris(tris(hydroxymethyl)aminomethane) guanosine-5'-tetraphosphate
EINECS	Contact for details

Quality Control

Our Guanosine 5'-Tetraphosphate Tris Salt is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and stringent tests for moisture and endotoxin levels where applicable. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the container to reach room temperature before opening to minimize moisture absorption. For long-term storage, consider desiccant or under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Assay (HPLC)	≥ 95%
Purity (HPLC)	≥ 98%
Water Content (KF)	≤ 5.0%
pH (1% Solution)	6.5 - 8.5
Endotoxin (LAL)	< 10 EU/mg (if specified)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.