Description

Guanosine 5'-Diphosphate, Periodate Oxidized Sodium Salt is a chemically modified nucleotide derivative where the ribose sugar ring has been selectively cleaved by periodate oxidation. This modification is critical for its role as a potent inhibitor of ribonucleotide reductases and other enzymes dependent on intact nucleotide cofactors. It is primarily utilized by researchers and manufacturers in biochemical research, pharmaceutical development, and enzymology studies to investigate nucleotide metabolism and enzyme mechanisms.

Application

• Enzyme Inhibition Studies: Used as a specific inhibitor for ribonucleotide reductase (RNR) and other nucleotide-binding enzymes to study reaction mechanisms and metabolic pathways.
• Biochemical Research Reagent: Serves as a key substrate analog in enzymatic assays and kinetic studies to understand nucleotide processing and regulation.
• Pharmaceutical Development: Investigated for potential therapeutic applications targeting abnormal cell proliferation, such as in cancer research, due to its ability to disrupt DNA synthesis.
• Metabolic Pathway Analysis: Employed in vitro to probe and map nucleotide salvage and de novo synthesis pathways in cellular models.
• Structural Biology: Used in X-ray crystallography and NMR studies to determine the three-dimensional structure of enzyme-inhibitor complexes.
• Diagnostic Kit Manufacturing: Incorporated as a component in specialized diagnostic assays for measuring enzyme activity levels in clinical samples.

Basic Information

Product Name	Guanosine 5'-Diphosphate, Periodate Oxidized Sodium Salt
CAS No.	103192-43-4
Molecular Formula	C10H12N5O11P2Na2
Molecular Weight	501.16 g/mol
Synonyms	Periodate-Oxidized GDP Sodium Salt; 2',3'-Dialdehyde GDP Sodium Salt; oGDP-Na2; GDP-dialdehyde Sodium Salt; Oxidized Guanosine Diphosphate Sodium Salt; Guanosine 5'-(trihydrogen diphosphate) 2',3'-(sodium aldehyde); 8-Oxo-GDP Sodium Salt (common misnomer); Gp4O Sodium Salt
EINECS	Contact for details

Quality Control

Our Guanosine 5'-Diphosphate, Periodate Oxidized Sodium Salt is produced under stringent conditions to ensure high purity and batch-to-batch consistency suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry for identity verification. Certificates of Analysis (COA) detailing all specifications are available upon request, and we can support compliance documentation for research use.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Allow the sealed container to reach room temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
pH (1% Solution)	6.0 - 8.0
Endotoxin	< 10 EU/mg (if specified)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.