Description

Adenylyl-(3'-5')-Guanosine is a defined dinucleotide monophosphate, a crucial building block in RNA synthesis and biochemical research. This high-purity compound is essential for studying nucleic acid structure, enzyme mechanisms, and oligonucleotide synthesis. It serves as a critical reagent for molecular biologists, biochemists, and pharmaceutical researchers developing novel therapeutics and diagnostic tools.

Application

• Biochemical Research: Used as a substrate or intermediate in enzymatic studies of RNA ligases, polymerases, and nucleotidyltransferases.
• Oligonucleotide Synthesis: Serves as a protected phosphodiester building block for the solid-phase or solution-phase synthesis of specific RNA sequences.
• Structural Biology: Employed in X-ray crystallography and NMR spectroscopy to investigate the three-dimensional structure and dynamics of RNA motifs and protein-RNA complexes.
• Enzyme Kinetics: Acts as a standard or tracer in assays measuring enzymatic activity and inhibition constants (Ki/IC50) for drug discovery.
• Diagnostic Development: Utilized in the design and production of probes, primers, and molecular beacons for nucleic acid detection and amplification.
• Pharmaceutical Reference Standard: Provides a characterized standard for quality control and regulatory filings in the production of RNA-based active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Adenylyl-(3'-5')-Guanosine
CAS No.	102029-53-8
Molecular Formula	C20H25N10O12P
Molecular Weight	628.44 g/mol
Synonyms	ApG; Adenosine(3'→5')guanosine; 3'-5' Adenylyl Guanosine; 3'-Adenylylguanosine; Adenosine 3'-monophospho-5'-guanosine; Guanosine, adenylyl-(3'→5')-; pA-G; GpA (isomer)
EINECS	Contact for details

Quality Control

Our Adenylyl-(3'-5')-Guanosine is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry for identity verification. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.