Description

6-n-Hydroxylaminopurine Deoxynucleoside Triphosphate is a chemically modified nucleotide triphosphate analog used in advanced biochemical research and development. This compound is critical for studying DNA replication, repair mechanisms, and for the development of novel diagnostic and therapeutic agents. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies specializing in molecular biology, enzymology, and next-generation sequencing technologies.

Application

• Enzymology Studies: Used as a substrate analog to investigate the activity and specificity of DNA polymerases and other nucleic acid-processing enzymes.
• DNA Sequencing & Synthesis: Employed in specialized next-generation sequencing (NGS) platforms and oligonucleotide synthesis for introducing specific modifications or probes.
• Mechanistic Biochemistry: A vital tool for probing DNA damage and repair pathways, helping to elucidate cellular responses to genotoxic stress.
• Drug Discovery: Serves as a building block in the development of nucleotide-based antiviral or anticancer prodrugs.
• Diagnostic Assay Development: Incorporated into probes for sensitive detection systems, including PCR-based diagnostics and biosensors.
• Bioconjugation & Labeling: Acts as a reactive intermediate for attaching fluorescent dyes, affinity tags, or other reporter molecules to nucleic acids.

Basic Information

Product Name	6-n-Hydroxylaminopurine Deoxynucleoside Triphosphate
CAS No.	101212-53-7
Molecular Formula	C10H17N6O13P3
Molecular Weight	546.19 g/mol
Synonyms	6-NH2OH-dATP; 6-(Hydroxyamino)purine 2'-deoxyriboside 5'-triphosphate; HAP-dNTP; 6-Hydroxylaminopurine deoxyribonucleoside triphosphate; 2'-Deoxyadenosine-5'-triphosphate, 6-(hydroxyamino)-; 6-Hydroxyaminopurine 2'-deoxyriboside triphosphate; dATP(N6-OH); Modified dATP analog
EINECS	Contact for details

Quality Control

Our 6-n-Hydroxylaminopurine Deoxynucleoside Triphosphate is manufactured under stringent quality systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the exacting standards required for sensitive research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, concentration, and absence of specific contaminants like nucleases.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a non-frost-free freezer. This product is hygroscopic (moisture-sensitive). For long-term stability, store desiccated. Aliquot to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white solid or lyophilized powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Assay (UV)	≥ 90% (anhydrous basis)
Water Content (KF)	≤ 5%
Solubility	Soluble in water or TE buffer
Biological Activity	Suitable for enzymatic incorporation

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.