Description

Netropsin Dihydrochloride Hydrate is a high-purity, biologically active minor groove-binding agent. This compound is critical for biochemical and pharmaceutical research, particularly in the study of DNA-protein interactions and as a tool compound in molecular biology. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in drug discovery and genetic analysis.

Application

• Biochemical Research: As a specific DNA minor groove binder for studying nucleic acid structure, dynamics, and protein-DNA recognition.
• Pharmaceutical R&D: A tool compound in screening assays and as a lead structure for developing novel antimicrobial or anticancer agents targeting DNA.
• Molecular Biology: Used in footprinting experiments to map protein binding sites on DNA and to investigate gene regulation mechanisms.
• Virology Studies: Research into antiviral compounds, given its ability to bind to specific DNA sequences and potentially inhibit viral replication.
• Academic Research: Fundamental studies in chemistry and biophysics to understand the principles of molecular recognition and binding affinity.

Basic Information

Product Name	Netropsin Dihydrochloride Hydrate
CAS No.	18133-22-7
Molecular Formula	C₁₈H₂₆N₁₀O₃ · 2HCl · xH₂O
Molecular Weight	563.42 g/mol (anhydrous free base)
Synonyms	Netropsin dihydrochloride; Congocidine dihydrochloride; Sinanomycin dihydrochloride; Antibiotic M-6889 dihydrochloride; 1-Methyl-4-[3-[2-(1-methyl-2-pyrrolylcarbonylamino)propionamido]propyl]-2-pyrrolecarboxamidine dihydrochloride hydrate; NSC-57153; Distamycin A analog
EINECS	Contact for details

Quality Control

Our Netropsin Dihydrochloride Hydrate is manufactured under controlled conditions to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and loss on drying. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to ensure full traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. Due to its hygroscopic nature, the container should be allowed to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 10.0%
Residue on Ignition	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.