Description

4-((8S,11R,13S,14S,17S)-17-hydroxy-13-methyl-3-oxo-17-(prop-1-yn-1-yl)-2,3,6,7,8,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-11-yl)-N,N-dimethylaniline oxide is a high-purity, complex steroid derivative with a defined stereochemistry, serving as a critical advanced intermediate in pharmaceutical research and development. Its precise molecular architecture makes it invaluable for the synthesis of novel therapeutic agents targeting hormone receptors and related pathways. This compound is primarily sought by research institutions and pharmaceutical companies engaged in the development of steroidal drugs, anti-inflammatory agents, and other specialized bioactive molecules.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of novel steroidal active pharmaceutical ingredients (APIs).
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the discovery of new drug candidates.
• Hormone Receptor Modulator Synthesis: Serves as a precursor for compounds designed to interact with glucocorticoid, mineralocorticoid, or other nuclear receptors.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and impurity profiling.
• Biochemical Research: Utilized in academic and industrial labs to study steroid metabolism and enzyme inhibition.

Basic Information

Product Name	4-((8S,11R,13S,14S,17S)-17-hydroxy-13-methyl-3-oxo-17-(prop-1-yn-1-yl)-2,3,6,7,8,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-11-yl)-N,N-dimethylaniline oxide
CAS No.	91934-98-4
Molecular Formula	C29H35NO3
Molecular Weight	445.60 g/mol
Synonyms	11β-(4-(Dimethylamino)phenyl)-17α-(prop-1-yn-1-yl)-estra-4,9-diene-3,17β-diol 17-oxide; 17-Hydroxy-13-methyl-3-oxo-17-(prop-1-ynyl)-2,3,6,7,8,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-11-yl)-N,N-dimethylaniline oxide; Mifepristone Impurity; RU 38486 related compound; Steroid aniline oxide derivative
EINECS	Contact for details

Quality Control

Our 4-((8S,11R,13S,14S,17S)-17-hydroxy-13-methyl-3-oxo-17-(prop-1-yn-1-yl)-2,3,6,7,8,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-11-yl)-N,N-dimethylaniline oxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral methods to confirm stereochemical integrity, ensuring it meets the exacting standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant use and inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.