Description

11Beta,16Alpha,17,21-Tetrahydroxypregn-4-Ene-3,20-Dione is a high-purity synthetic steroid derivative with significant pharmaceutical research and development value. This compound serves as a critical intermediate in the synthesis of potent glucocorticoids and other specialized steroid-based active pharmaceutical ingredients (APIs). It is essential for pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions engaged in advanced steroid chemistry and drug discovery. Our supply is characterized by stringent quality control to ensure batch-to-batch consistency for your most demanding applications.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of advanced corticosteroid APIs, including anti-inflammatory agents.
• Research & Development: Used in medicinal chemistry programs to develop novel glucocorticoid receptor modulators with improved therapeutic profiles.
• Reference Standard: Serves as an analytical standard for quality control and method validation in pharmaceutical laboratories.
• Process Chemistry: Employed in scale-up and optimization studies for the commercial production of steroid-based drugs.
• Biochemical Research: Utilized in studies investigating steroid hormone metabolism, receptor binding, and signal transduction pathways.

Basic Information

Product Name	11Beta,16Alpha,17,21-Tetrahydroxypregn-4-Ene-3,20-Dione
CAS No.	1171-81-9
Molecular Formula	C21H30O6
Molecular Weight	378.46 g/mol
Synonyms	11β,16α,17,21-Tetrahydroxypregn-4-ene-3,20-dione; 11β,16α-Dihydroxycortisol; 11β,16α,17,21-Tetrahydroxyprogesterone; 11β,16α-Dihydroxy Compound S; 11β,16α,17α,21-Tetrahydroxy-4-pregnene-3,20-dione; 11β,16α-Dihydroxy-17α,21-dihydroxypregn-4-ene-3,20-dione; 11β,16α-Dihydroxycorticosterone
EINECS	Contact for details

Quality Control

Our 11Beta,16Alpha,17,21-Tetrahydroxypregn-4-Ene-3,20-Dione is manufactured under a quality management system and undergoes rigorous analytical testing to ensure it meets the high standards required for pharmaceutical research. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We can support development projects requiring compliance with ICH guidelines and current Good Manufacturing Practice (cGMP) principles for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.