Description

(8S,10S)-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-10-[(2S,4S,5S,6S)-5-hydroxy-6-methyl-4-morpholin-4-yl-oxan-2-yl]oxy-1-methoxy-9,10-dihydro-7H-tetracene-5,12-dione hydrochloride is a high-purity, complex anthracycline derivative and a key pharmaceutical intermediate. Its primary value lies in its role as a critical building block for the synthesis of advanced oncology drugs and other specialized therapeutic agents. This compound is essential for research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of novel cancer treatments and complex small-molecule APIs.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of sophisticated anthracycline-based chemotherapeutic agents.
• Oncology Drug Research & Development: Used as a reference standard and building block in the discovery and development of new anti-cancer compounds targeting DNA intercalation and topoisomerase inhibition.
• Active Pharmaceutical Ingredient (API) Synthesis: Integral to the manufacturing process of specific, high-potency prescription medications.
• Biochemical Research: Employed in academic and industrial laboratories to study the structure-activity relationships (SAR) of anthracycline molecules and their mechanisms of action.
• Process Chemistry & Scale-Up: Used by CDMOs for process optimization, route scouting, and the production of clinical trial materials (CTM) and commercial API batches.

Basic Information

Product Name	(8S,10S)-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-10-[(2S,4S,5S,6S)-5-hydroxy-6-methyl-4-morpholin-4-yl-oxan-2-yl]oxy-1-methoxy-9,10-dihydro-7H-tetracene-5,12-dione hydrochloride
CAS No.	89196-04-3
Molecular Formula	C32H36ClNO13
Molecular Weight	678.08 g/mol
Synonyms	4-Demethoxy-7-O-(2,6-dideoxy-4-O-(2,3,6-trideoxy-3-amino-α-L-lyxo-hexopyranosyl)-α-L-lyxo-hexopyranosyl)adriamycinone hydrochloride; 4'-Epi-daunorubicin hydrochloride; 4'-Epidoxorubicin impurity; Idarubicin related compound; Anthracycline derivative hydrochloride; 4-Demethoxydaunorubicin HCl; 4-Demethoxy-7-O-(2,6-dideoxy-4-O-(2,3,6-trideoxy-3-amino-α-L-lyxo-hexopyranosyl)-α-L-lyxo-hexopyranosyl)adriamycinone HCl
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and traceability. Quality is verified through comprehensive analytical testing, including HPLC for purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key parameters such as assay, related substances, and residual solvents. We support development and commercial projects requiring compliance with cGMP and ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	Orange to red powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 3.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.