Description

Methyl (1R,2R,4S)-4-[(2S,4S,5S,6S)-4-dimethylamino-5-[(2S,4S,5R,6S)-4-hydroxy-6-methyl-5-[[(2S,6S)-6-methyl-5-oxo-2H-pyran-2-yl]oxy]oxan-2-yl]oxy-6-methyl-oxan-2-yl]oxy-2-ethyl-2,5,7,10-tetrahydroxy-6,11-dioxo-3,4-dihydro-1H-tetracene-1-carboxylate is a structurally complex, high-purity chemical intermediate with significant relevance in advanced pharmaceutical synthesis. This compound is valued for its precise stereochemistry and functional groups, which make it a critical building block for the development of novel therapeutic agents. It is primarily sought by research institutions and pharmaceutical companies engaged in the synthesis of complex natural product derivatives and targeted small molecule drugs.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for antibiotics and anticancer agents.
• Organic Synthesis Research: Used in academic and industrial laboratories for studying complex glycosylation and polyketide coupling reactions.
• Process Chemistry Development: Employed in scaling up synthetic routes for complex molecules, aiding in route scouting and optimization.
• Reference Standard: Can be utilized as a high-purity analytical standard for method development and quality control in pharmaceutical manufacturing.
• Bioconjugation Chemistry: Potential use in the synthesis of antibody-drug conjugates (ADCs) or other targeted drug delivery systems due to its reactive handles.

Basic Information

Product Name	Methyl (1R,2R,4S)-4-[(2S,4S,5S,6S)-4-dimethylamino-5-[(2S,4S,5R,6S)-4-hydroxy-6-methyl-5-[[(2S,6S)-6-methyl-5-oxo-2H-pyran-2-yl]oxy]oxan-2-yl]oxy-6-methyl-oxan-2-yl]oxy-2-ethyl-2,5,7,10-tetrahydroxy-6,11-dioxo-3,4-dihydro-1H-tetracene-1-carboxylate
CAS No.	88477-80-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Methyl 4-O-(4-Dimethylamino-5-O-(4-hydroxy-6-methyl-5-O-(6-methyl-5-oxo-2H-pyran-2-yl)oxan-2-yl)oxy-6-methyloxan-2-yl)oxy-2-ethyl-2,5,7,10-tetrahydroxy-6,11-dioxo-3,4-dihydro-1H-tetracene-1-carboxylate; 88477-80-9; Aclacinomycin A methyl ester derivative; Aclacinomycin intermediate; Anthracycline glycoside derivative; (1R,2R,4S)-1-(Methoxycarbonyl)-2-ethyl-2,5,7,10-tetrahydroxy-6,11-dioxo-3,4-dihydro-1H-tetracen-4-yl trisaccharide derivative
EINECS	Contact for details

Quality Control

Our methyl (1R,2R,4S)-4-[(2S,4S,5S,6S)-4-dimethylamino-5-[(2S,4S,5R,6S)-4-hydroxy-6-methyl-5-[[(2S,6S)-6-methyl-5-oxo-2H-pyran-2-yl]oxy]oxan-2-yl]oxy-6-methyl-oxan-2-yl]oxy-2-ethyl-2,5,7,10-tetrahydroxy-6,11-dioxo-3,4-dihydro-1H-tetracene-1-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, LC-MS) are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture uptake. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to orange-brown powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Chiral Purity	≥ 98.0% de
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.