Description

5,12-Naphthacenedione, 10-(2R,4S,5S,6S)-4-aminotetrahydro-5-iodo-6-methyl-2H-pyran-2-yloxy-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, (8S,10S)- is a structurally complex, iodinated anthracycline derivative of significant interest in advanced pharmaceutical research and development. Its intricate molecular architecture, featuring a naphthacenedione core and an amino sugar moiety, makes it a valuable intermediate for the synthesis of novel bioactive compounds. This high-purity chemical is primarily targeted at research institutions and pharmaceutical companies engaged in oncology drug discovery, chemical biology, and the development of new antibiotic agents.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel anthracycline-based chemotherapeutic agents and antibiotics.
• Oncology Research: Used in biochemical and pharmacological studies to investigate mechanisms of action against cancer cell lines, leveraging its DNA-intercalating potential.
• Chemical Biology Probe: Acts as a structurally complex scaffold for developing molecular probes to study enzyme interactions and cellular pathways.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the production of complex active pharmaceutical ingredients (APIs).
• Reference Standard: Utilized as a high-purity analytical standard for method development and quality control in pharmaceutical manufacturing.
• Academic Research: Supports synthetic organic chemistry projects focused on the modification of natural product derivatives for enhanced efficacy or reduced toxicity.

Basic Information

Item	Details
Product Name	5,12-Naphthacenedione, 10-(2R,4S,5S,6S)-4-aminotetrahydro-5-iodo-6-methyl-2H-pyran-2-yloxy-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, (8S,10S)-
CAS No.	83997-75-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	10-[(2R,4S,5S,6S)-4-Amino-5-iodo-6-methyltetrahydro-2H-pyran-2-yl]oxy-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione; Iodinated Anthracycline Derivative; 5-Iodo-4-demethoxy-7-O-(2,6-dideoxy-4-O-(2-hydroxyacetyl)-α-L-lyxo-hexopyranosyl)adriamycinone analog; Complex Anthracycline Intermediate; (8S,10S)-10-[(2R,4S,5S,6S)-4-Amino-5-iodo-6-methyltetrahydro-2H-pyran-2-yl]oxy-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione
EINECS	Contact for details

Quality Control

Our 5,12-Naphthacenedione derivative is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and development applications. Each lot undergoes comprehensive analytical characterization, including chromatographic purity assays and structural confirmation. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed in a desiccated environment away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	Orange to red-brown powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH limits
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.