Description

(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylic dimethylcarbamic thioanhydride is a high-purity, complex steroid derivative designed for advanced pharmaceutical research and development. This compound serves as a critical synthetic intermediate or reference standard in the development of novel therapeutic agents, particularly in the fields of endocrinology and anti-inflammatory drug discovery. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require precise, well-characterized building blocks for complex organic synthesis.

Application

• Pharmaceutical Intermediate: Key building block in the multi-step synthesis of novel corticosteroid analogs and other steroidal active pharmaceutical ingredients (APIs).
• Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control in pharmaceutical laboratories.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies to explore the impact of fluorination and thioanhydride modification on biological activity and metabolic stability.
• Process Development: Serves as a critical intermediate for scaling up synthetic routes under current Good Manufacturing Practice (cGMP) conditions for clinical trial material production.
• Biochemical Research: Potential tool compound for investigating steroid hormone receptor interactions and signaling pathways in preclinical models.

Basic Information

Item	Detail
Product Name	(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylic dimethylcarbamic thioanhydride
CAS No.	709002-84-6
Molecular Formula	C24H29F2NO5S
Molecular Weight	481.55 g/mol
Synonyms	6,9-Difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylic acid dimethylcarbamic thioanhydride; 17-Carboxy-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethylandrosta-1,4-diene-3-one dimethylcarbamothioic anhydride; Difluorinated Steroid Thioanhydride; CAS 709002-84-6
EINECS	Contact for details

Quality Control

Our pharmaceutical-grade steroid intermediates are produced and tested under a rigorous quality management system. Each batch is analyzed to meet stringent in-house specifications, with testing typically including identity confirmation by spectroscopic methods (IR, NMR), purity assessment by HPLC, and control of related substances. A comprehensive Certificate of Analysis (COA) detailing all test results and methods is provided with every shipment to ensure full traceability and support your regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. Keep the container sealed to protect this light-sensitive material from degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.