Description

5,12-Naphthacenedione, 8-acetyl-10-[[3-(cyclohexylamino)-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, hydrochloride, (8S-cis)- is a complex, high-purity synthetic chemical intermediate of significant interest in advanced pharmaceutical research and development. Its intricate molecular architecture, featuring a naphthacenedione core linked to an amino sugar moiety, makes it a critical precursor for the synthesis of specialized bioactive compounds. This product is essential for R&D chemists and process development scientists working in oncology and antibiotic drug discovery, where precise molecular construction is paramount.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthetic pathways for novel anthracycline and tetracycline analogue antibiotics.
• Oncology Research: Used in the development and study of potential chemotherapeutic agents targeting DNA intercalation and topoisomerase inhibition.
• Biochemical Research: Employed as a reference standard or probe in studies of drug-receptor interactions and mechanism-of-action analysis.
• Process Chemistry: Utilized in scale-up and optimization studies for the production of active pharmaceutical ingredients (APIs) with complex glycosylated structures.
• Academic Research: Provides a sophisticated substrate for methodological development in organic synthesis and medicinal chemistry at university and institutional labs.

Basic Information

Item	Detail
Product Name	5,12-Naphthacenedione, 8-acetyl-10-[[3-(cyclohexylamino)-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, hydrochloride, (8S-cis)-
CAS No.	79898-09-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	8S-cis-8-Acetyl-10-[(3-(cyclohexylamino)-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione Hydrochloride; Daunorubicin Derivative; 4-Demethoxy-7,9-O,O-bis(2,3,6-trideoxy-3-amino-α-L-lyxo-hexopyranosyl)daunomycinone Hydrochloride (related structure); Anthracycline Aminoglycoside Intermediate; (8S-cis)-Daunorubicin analogue hydrochloride; 79898-09-2; Cyclohexylamino-deoxyhexopyranosyl naphthacenedione hydrochloride.
EINECS	Contact for details

Quality Control

Our high-purity chemical intermediate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, IR), to ensure it meets the exacting standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting critical parameters such as assay purity, related substances, and residual solvents. We support compliance with ICH guidelines for stability and impurity profiling.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and handled under appropriate conditions to prevent degradation.

Specification

Item	Specification
Appearance	Orange to red-brown powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.