Description

10-[[3-Amino-4-O-[3-hydroxy-1-(2-hydroxy-1-methylethoxy)butyl]-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-1,6,8,11-tetrahydroxy-8-(1-hydroxyethyl)-5,12-naphthacenedione is a complex, semi-synthetic anthracycline derivative of significant interest in advanced pharmaceutical research. This compound matters as a key intermediate or potential active pharmaceutical ingredient (API) in the development of novel chemotherapeutic agents, leveraging the potent DNA-intercalating properties of the naphthacenedione core. It is primarily needed by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers focused on oncology drug discovery and the synthesis of next-generation antitumor antibiotics.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the multi-step synthesis of novel anthracycline-based chemotherapeutic agents.
• Oncology Research: Used as a reference standard or experimental compound in biochemical and pharmacological studies targeting DNA topoisomerase II inhibition.
• API Development: Investigated as a potential active pharmaceutical ingredient (API) for the formulation of injectable anti-cancer drugs.
• Mechanistic Studies: Employed in academic and industrial research to understand structure-activity relationships (SAR) within the anthracycline drug class.
• Process Chemistry: Utilized in the development and scale-up of synthetic routes for complex glycosylated natural product derivatives.

Basic Information

Product Name	10-[[3-Amino-4-O-[3-hydroxy-1-(2-hydroxy-1-methylethoxy)butyl]-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-1,6,8,11-tetrahydroxy-8-(1-hydroxyethyl)-5,12-naphthacenedione
CAS No.	78366-45-7
Molecular Formula	C₃₄H₄₅NO₁₆
Molecular Weight	723.72 g/mol
Synonyms	4'-O-Tetrahydropyranyl Doxorubicin; THP-Doxorubicin; Pirarubicin Intermediate; (8S,10S)-10-[[(2R,4S,5S,6S)-4-Amino-5-hydroxy-6-methyloxan-2-yl]oxy]-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione derivative; 4'-O-THP-Adriamycin; Tetrahydropyranyl Adriamycin; 4'-O-(2-Tetrahydropyranyl)doxorubicin; An anthracycline glycoside derivative.
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to strict quality management protocols, ensuring batch-to-batch consistency for research and development purposes. Quality is verified through a battery of analytical techniques including HPLC for purity and assay, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and handled under appropriate conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	Orange to red powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95.0%
Assay (HPLC)	97.0% - 102.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.