Description

(1R)-1,2,3,4,6,11-Hexahydro-4α-[[3-(methylamino)-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl]oxy]-6,11-dioxo-2-ethyl-2α,5,7-trihydroxy-1β-naphthacenecarboxylic acid methyl ester is a complex, semi-synthetic tetracycline derivative of significant interest in advanced pharmaceutical research and development. This compound matters for its potential as a key intermediate or active pharmaceutical ingredient (API) in the synthesis of next-generation antibiotics targeting resistant bacterial strains. It is primarily needed by pharmaceutical manufacturers, biotechnology research firms, and academic institutions engaged in the development of novel anti-infective therapies and chemical biology studies.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel tetracycline-class antibiotics.
• Active Pharmaceutical Ingredient (API) Research: Used in preclinical and clinical research for developing new antibacterial agents.
• Biochemical Research: Employed in studies investigating protein synthesis inhibition and bacterial ribosome interaction mechanisms.
• Reference Standard: Utilized as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Chemical Synthesis: Acts as a starting material or advanced intermediate for the preparation of structurally modified tetracycline analogs.

Basic Information

Item	Details
Product Name	(1R)-1,2,3,4,6,11-Hexahydro-4α-[[3-(methylamino)-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl]oxy]-6,11-dioxo-2-ethyl-2α,5,7-trihydroxy-1β-naphthacenecarboxylic acid methyl ester
CAS No.	67508-85-4
Molecular Formula	C₂₈H₃₄N₂O₁₁
Molecular Weight	574.58 g/mol
Synonyms	Methyl (1R,2S,4S,5R,6S,12aS)-2-Ethyl-4-(hydroxy)-5,6,10,11,12a-pentahydroxy-6-methyl-4a,5a,6,12a-tetrahydro-4H-tetracene-1-carboxylate; 6-Deoxy-6-demethyl-6-methylene-5-oxytetracycline methyl ester derivative; A derivative of Sancycline; 2-Ethyl-4α-(3-methylamino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyloxy)-1,2,3,4,6,11-hexahydro-6,11-dioxo-2α,5,7-trihydroxy-1β-naphthacenecarboxylic acid methyl ester; Tetracene antibiotic intermediate.
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for pharmaceutical intermediates. Each batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity and purity. Certificates of Analysis (COA) detailing specific test results are available upon request. We adhere to a quality management system to ensure traceability and consistency for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.