Description

(8S)-8-Acetyl-10α-[[3-amino-4-O-[1-(1-carboxyethoxy)-3-hydroxybutyl]-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione is a structurally complex, semi-synthetic anthracycline derivative. This compound is of significant interest in advanced pharmaceutical research and development, particularly for its potential as a key intermediate or active moiety in novel therapeutic agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis and evaluation of next-generation oncology treatments and antibiotics.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel anthracycline-based chemotherapeutic agents.
• Oncology Research: Used in preclinical studies to develop new anti-cancer drugs with potentially improved efficacy or reduced side-effect profiles.
• Antibiotic Development: Investigated for the creation of new antibiotic compounds to combat resistant bacterial strains.
• Biochemical Research: Employed as a standard or probe in studies focusing on DNA intercalation and topoisomerase inhibition mechanisms.
• Process Chemistry: Used in scale-up and optimization studies for the manufacturing of complex active pharmaceutical ingredients (APIs).
• Academic Research: Utilized in university and institutional labs for synthetic chemistry and medicinal chemistry projects.

Basic Information

Product Name	(8S)-8-Acetyl-10α-[[3-amino-4-O-[1-(1-carboxyethoxy)-3-hydroxybutyl]-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione
CAS No.	64253-72-1
Molecular Formula	C34H41NO15
Molecular Weight	703.69 g/mol
Synonyms	4'-O-(1-Carboxyethyl)adriamycin; 4'-O-(1-Carboxyethyl)doxorubicin; 4'-O-(1-Carboxyethyl)-DOX; 4'-O-(1-Carboxyethyl)doxorubicinone; 4'-O-(1-Carboxyethyl)adriamycinone; 4'-O-(1-Carboxyethyl)-14-hydroxydaunomycin; (8S)-8-Acetyl-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione 10-(4-O-(1-carboxyethyl)-3-hydroxybutanoate)
EINECS	Contact for details

Quality Control

Our (8S)-8-Acetyl-10α-[[3-amino-4-O-[1-(1-carboxyethoxy)-3-hydroxybutyl]-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. Keep the container in a dry, well-ventilated area. For long-term storage, consider storing under inert atmosphere to ensure stability.

Specification

Item	Specification
Appearance	Orange to red powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.