Description

Pregna-1,4-diene-3,20-dione, 21,21'-[methylenebis[(2-methoxy-1,3-naphthalenediyl)carbonyloxy]]bis[9-fluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-, (11beta,16alpha)-(11'beta,16'alpha)- is a complex, high-purity synthetic corticosteroid derivative of significant interest in advanced pharmaceutical research and development. This compound matters for its potential as a key intermediate or active pharmaceutical ingredient (API) in the synthesis of novel, potent anti-inflammatory and immunosuppressive agents. It is primarily needed by pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and fine chemical suppliers serving the global life sciences sector.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the multi-step synthesis of novel corticosteroid-based APIs.
• Research & Development: Used in medicinal chemistry programs to develop new therapeutic agents targeting inflammation, autoimmune disorders, and allergic conditions.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and impurity profiling of related steroid compounds.
• Process Chemistry: Utilized in scale-up and optimization studies for the commercial manufacturing of specialized steroid pharmaceuticals.
• Biochemical Research: Applied in studies investigating glucocorticoid receptor interactions and the mechanisms of steroid action.

Basic Information

Product Name	Pregna-1,4-diene-3,20-dione, 21,21'-[methylenebis[(2-methoxy-1,3-naphthalenediyl)carbonyloxy]]bis[9-fluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-, (11beta,16alpha)-(11'beta,16'alpha)-
CAS No.	55461-42-2
Molecular Formula	C58H62F2O14
Molecular Weight	997.11 g/mol
Synonyms	21,21'-[Methylenebis[(2-methoxy-1,3-naphthalenediyl)carbonyloxy]]bis[9-fluoro-11β,16α,17α-trihydroxypregna-1,4-diene-3,20-dione 16,17-acetonide; Difluprednate Impurity; Difluprednate Related Compound; 9α,11β,16α,17α,21-Pentahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with acetone 21-(3-methoxy-1-naphthoate) dimer; Steroid Dimer Intermediate; Corticosteroid Dimer; (11β,16α)-9-Fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with acetone 21-[3-[(2-methoxy-1,3-naphthalenediyl)carbonyloxy]-1-naphthoate]
EINECS	Contact for details

Quality Control

Our high-purity steroid intermediates are manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and related substances, identity confirmation by spectroscopic methods (IR, NMR), and residual solvent analysis to ensure compliance with ICH guidelines. A detailed Certificate of Analysis (COA) documenting all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.