Description

5,12-Naphthacenedione, 8-acetyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-10-2,3,6-trideoxy-3-(methoxycarbonyl)amino-.alpha.-L-lyxo-hexopyranosyloxy-, (8S-cis)- is a complex, high-purity anthracycline derivative with significant research and development value. This compound matters for its role as a key intermediate or reference standard in the synthesis and study of novel pharmaceutical agents, particularly in oncology. It is primarily needed by R&D laboratories, pharmaceutical manufacturers, and academic institutions focused on developing new chemotherapeutic drugs and studying structure-activity relationships.

Application

• Pharmaceutical Research & Development (R&D): Serves as a critical intermediate or building block in the synthesis of novel anthracycline-based chemotherapeutic agents.
• Reference Standard for Analytical Chemistry: Used as a high-purity standard for method development, validation, and quality control (HPLC, LC-MS) in pharmaceutical analysis.
• Biochemical Research: Employed in studies investigating the mechanisms of action, DNA intercalation, and topoisomerase inhibition associated with anthracycline compounds.
• Academic Research: Utilized in university and institutional labs for chemical synthesis projects and pharmacological studies related to cancer treatment.
• Process Chemistry Development: Acts as a starting material or intermediate for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions for Active Pharmaceutical Ingredient (API) production.

Basic Information

Product Name	5,12-Naphthacenedione, 8-acetyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-10-2,3,6-trideoxy-3-(methoxycarbonyl)amino-.alpha.-L-lyxo-hexopyranosyloxy-, (8S-cis)-
CAS No.	38942-79-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	8-Acetyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-10-[2,3,6-trideoxy-3-[(methoxycarbonyl)amino]-α-L-lyxo-hexopyranosyloxy]-5,12-naphthacenedione; (8S-cis)-Isomer; Daunorubicin derivative; Anthracycline glycoside intermediate; 4-Demethoxy-7-O-(2,6-dideoxy-3-C-methyl-α-L-ribo-hexopyranosyl)adriamycinone derivative; 38942-79-9; Carminomycin I derivative
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We employ advanced analytical techniques including HPLC, NMR, and mass spectrometry to verify identity, purity, and potency. Certificates of Analysis (COA) detailing batch-specific results are available upon request. Our quality systems support development under research and cGMP guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	Orange to red-brown powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.