Description

(8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylic acid is a high-purity synthetic steroid derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical pharmaceutical intermediate for the synthesis of potent glucocorticoid receptor agonists. It is primarily utilized by pharmaceutical manufacturers and contract research organizations (CROs) engaged in the development of novel anti-inflammatory and immunosuppressive therapies.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of advanced corticosteroid active pharmaceutical ingredients (APIs).
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies to develop new glucocorticoid receptor modulators.
• Process Chemistry: Serves as a reference standard and starting material for optimizing scalable manufacturing routes for steroid-based drugs.
• Analytical Standard: Employed as a high-purity certified reference material (CRM) for quality control and method validation in analytical laboratories.

Basic Information

Product Name	(8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylic acid
CAS No.	37926-75-3
Molecular Formula	C₂₁H₂₇FO₅
Molecular Weight	378.44 g/mol
Synonyms	9-Fluoro-11β,17-dihydroxy-10β,13β,16α-trimethyl-3-oxo-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydrocyclopenta[a]phenanthrene-17β-carboxylic acid; 9α-Fluoro-11β,17-dihydroxy-10β,13β,16α-trimethyl-3-oxo-androsta-1,4-diene-17β-carboxylic acid; Fluticasone Impurity; Fluticasone Propionate Intermediate; Fluticasone Related Compound; 17-Carboxy Fluticasone Derivative; GR-1214 Intermediate
EINECS	Contact for details

Quality Control

Our production of this pharmaceutical intermediate adheres to stringent cGMP guidelines to ensure batch-to-batch consistency and traceability. Quality is verified through a comprehensive suite of analytical techniques including HPLC for purity and impurity profiling, NMR and IR for structural confirmation, and KF titration for moisture content. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.