Description

(6α,11β,16α,17α)-6,9-difluoro-11,17-dihydroxy-16-Methyl-3-oxo-Androsta-1,4-diene-17-carboxylic Acid (6α,11β,16α,17α)-6,9-difluoro-17-[[(fluoroMethyl)thio]carbonyl]-11-hydroxy-16-Methyl-3-oxoandrosta-1,4-dien-17-yl Ester is a highly specialized fluorinated steroid derivative with a complex molecular architecture. This compound is of significant interest in advanced pharmaceutical research and development, particularly as a key synthetic intermediate or a potential active pharmaceutical ingredient (API) precursor. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel corticosteroid or anti-inflammatory agents. The precise structural modifications, including multiple fluorine atoms and a unique ester linkage, are designed to impart specific biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the multi-step synthesis of novel corticosteroid drugs.
• Anti-inflammatory Research: Used in preclinical studies to develop new therapeutic agents targeting inflammatory pathways.
• Metabolic Stability Studies: The fluorinated structure makes it valuable for investigating drug metabolism and pharmacokinetics (DMPK).
• Structure-Activity Relationship (SAR) Analysis: A key compound for medicinal chemists to understand how specific molecular modifications affect biological potency.
• Reference Standard: Utilized as an analytical standard in quality control laboratories for method development and impurity profiling.
• Biochemical Research: Employed in studies exploring steroid hormone receptor interactions and signaling mechanisms.

Basic Information

Item	Details
Product Name	(6α,11β,16α,17α)-6,9-difluoro-11,17-dihydroxy-16-Methyl-3-oxo-Androsta-1,4-diene-17-carboxylic Acid (6α,11β,16α,17α)-6,9-difluoro-17-[[(fluoroMethyl)thio]carbonyl]-11-hydroxy-16-Methyl-3-oxoandrosta-1,4-dien-17-yl Ester
CAS No.	220589-37-7
Molecular Formula	C24H28F3O6S
Molecular Weight	501.54 g/mol
Synonyms	6α,9α-Difluoro-11β,17α,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 17-(fluoromethylthiocarbonate); 6α,9α-Difluoro-16α-methylprednisolone 17-(fluoromethylthiocarbonate); Fluorometholone 17-(fluoromethylthiocarbonate) derivative; 6α,9α-Difluoro-11β-hydroxy-16α-methyl-17α-[(fluoromethylthio)carbonyl]oxy-androsta-1,4-diene-3-one; 17α-[(Fluoromethylthio)carbonyl]-6α,9α-difluoro-11β,21-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione; CAS 220589-37-7; Difluorinated steroid thiocarbonate ester
EINECS	Contact for details

Quality Control

Our production of this high-purity steroid intermediate adheres to stringent quality management systems. Every batch is subjected to comprehensive analytical testing, including HPLC for purity and impurity profiling, NMR and IR for structural confirmation, and residual solvent analysis to ensure compliance with ICH guidelines. Certificates of Analysis (COA) detailing all specifications and test results are provided with each shipment to guarantee traceability and batch-to-batch consistency for your critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label. The container should be kept in a dry, well-ventilated area. For long-term storage, consider inert atmosphere conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.