Description

(8S,10S)-8-Acetyl-10-[[4-O-(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)-3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione is a structurally complex anthracycline derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical intermediate or reference standard for the synthesis and analysis of novel chemotherapeutic agents. It is primarily sought by research institutions and pharmaceutical companies engaged in oncology drug discovery, process development, and analytical method validation.

Application

• Pharmaceutical Intermediate: Key building block in the synthetic pathways for novel anthracycline-based anticancer drugs.
• Reference Standard: High-purity material for qualitative and quantitative analysis (HPLC, LC-MS) in drug development and quality control laboratories.
• Biochemical Research: Tool compound for studying structure-activity relationships (SAR), DNA intercalation mechanisms, and topoisomerase inhibition.
• Process Chemistry: Used in scaling up and optimizing manufacturing processes for complex active pharmaceutical ingredients (APIs).
• Academic Research: Investigated for its biological activity and potential in developing new therapeutic modalities against resistant cancer cell lines.

Basic Information

Product Name	(8S,10S)-8-Acetyl-10-[[4-O-(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)-3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione
CAS No.	28008-54-0
Molecular Formula	C₃₄H₄₀N₂O₁₅
Molecular Weight	716.69 g/mol
Synonyms	4'-O-(3-Amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)daunorubicin; 4'-O-(3-Amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)-13-dihydrodaunomycin; 4'-Epi-N,N-dimethyl-13-dihydrodaunorubicin; Aclacinomycin A aglycone derivative; 4'-O-(3-Amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)daunomycin; 4'-Epi-N,N-dimethyldaunorubicin aglycone; Anthracycline glycoside intermediate
EINECS	Contact for details

Quality Control

Every batch of our (8S,10S)-8-Acetyl-10-[[4-O-(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)-3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione is manufactured and analyzed under a strict quality management system. We provide comprehensive analytical data to support its use in regulated environments, including full characterization by NMR, MS, and HPLC. A Certificate of Analysis (COA) detailing purity, identity, and impurity profile is supplied with each shipment to ensure traceability and compliance with your research or development protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and degradation. For long-term storage, desiccate to protect against moisture. Allow the sealed container to reach room temperature before opening to minimize condensation.

Specification

Item	Specification
Appearance	Red to orange-red powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95.0% (Area Percent)
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.