Description

[(6S,8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-chloroacetyl)-6,9-difluoro-17-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-11-yl] propanoate is a high-purity synthetic steroid derivative, specifically a halogenated glucocorticoid analog, designed for advanced pharmaceutical research and development. This compound is critical for its potent biological activity and serves as a key intermediate or reference standard in the synthesis of novel therapeutic agents. It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in endocrinology, anti-inflammatory drug discovery, and metabolic disease research.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel glucocorticoid receptor agonists and antagonists.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control (QC/QA) of related steroid-based APIs.
• Biochemical Research: Employed in in vitro and in vivo studies to investigate steroid hormone receptor interactions, signaling pathways, and gene regulation.
• Drug Discovery: Serves as a lead compound or a structural template for medicinal chemistry programs targeting inflammatory, autoimmune, and allergic disorders.
• Metabolite Studies: Used in the identification and quantification of steroid metabolites in pharmacokinetic and pharmacodynamic research.

Basic Information

Product Name	[(6S,8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-chloroacetyl)-6,9-difluoro-17-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-11-yl] propanoate
CAS No.	181527-42-4
Molecular Formula	C25H30ClF2O5
Molecular Weight	483.96 g/mol
Synonyms	6α,9α-Difluoro-11β,17α-dihydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carboxylic acid γ-lactone 17-propionate; 17-(2-Chloroacetyl)-6,9-difluoro-17-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-11-yl propanoate; Halogenated glucocorticoid propanoate derivative; Clascoterone related compound; Cortexolone 17-propionate derivative; Steroid C-17 chloroacetate.
EINECS	Contact for details

Quality Control

Our [(6S,8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-chloroacetyl)-6,9-difluoro-17-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-11-yl] propanoate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for stereochemical integrity, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption, which may affect stability and purity. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.