Description

2-Fluoro-5-(1-Hydroxyethyl)Benzonitrile is a versatile fluorinated aromatic nitrile building block with a chiral secondary alcohol functional group. This compound is of significant value in advanced organic synthesis, particularly for the construction of complex molecules in pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists in the fine chemical and pharmaceutical intermediates sectors.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of active pharmaceutical ingredients (APIs), especially in kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, where the fluorine atom and nitrile group enhance biological activity and stability.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystal compounds for display technologies.
• Organic Electronic Materials: Employed in the development of novel organic semiconductors and charge-transport materials.
• Cross-Coupling Reactions: The aromatic fluoride and nitrile groups make it a suitable substrate for palladium-catalyzed cross-coupling reactions like Suzuki-Miyaura and Buchwald-Hartwig amination.
• Asymmetric Synthesis: The chiral hydroxyethyl side chain is valuable for constructing stereocenters in complex natural products and chiral ligands.

Basic Information

Item	Details
Product Name	2-Fluoro-5-(1-Hydroxyethyl)Benzonitrile
CAS No.	960244-29-5
Molecular Formula	C9H8FNO
Molecular Weight	165.16 g/mol
Synonyms	5-(1-Hydroxyethyl)-2-fluorobenzonitrile; 2-Fluoro-5-(1-hydroxyethyl)benzonitrile; 2-Fluoro-5-(α-hydroxyethyl)benzonitrile; (2-Fluoro-5-cyanophenyl)ethanol; 1-(5-Cyano-2-fluorophenyl)ethanol; α-Methyl-2-fluoro-5-cyanobenzyl alcohol; 960244-29-5
EINECS	Contact for details

Quality Control

Our 2-Fluoro-5-(1-Hydroxyethyl)Benzonitrile is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity, chiral HPLC for enantiomeric excess (where applicable), and NMR/IR for structural confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed specifications are provided for each lot.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using a desiccant.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	Contact for details (Racemic or Enantiopure)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.