Description

2-Chloro-4-(Trifluoromethyl)Benzonitrile is a versatile halogenated aromatic nitrile building block, distinguished by its trifluoromethyl and chloro substituents. This compound is highly valued for its role in facilitating the synthesis of complex molecules, particularly in advanced pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders and anti-inflammatory applications.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated compounds for electronic display technologies and organic light-emitting diodes (OLEDs).
• Functional Material Development: Employed in creating specialty polymers, dyes, and pigments that require specific electronic or steric properties.
• Cross-Coupling Reactions: An effective substrate for Suzuki, Sonogashira, and other palladium-catalyzed cross-coupling reactions to construct biaryl systems.
• Chemical Research & Development: A valuable building block in academic and industrial R&D for exploring new chemical spaces and reaction methodologies.

Basic Information

Item	Detail
Product Name	2-Chloro-4-(Trifluoromethyl)Benzonitrile
CAS No.	1813-33-8
Molecular Formula	C8H3ClF3N
Molecular Weight	205.56 g/mol
Synonyms	2-Chloro-α,α,α-trifluoro-p-tolunitrile; 4-Cyano-3-chlorobenzotrifluoride; 2-Chloro-4-(trifluoromethyl)benzenecarbonitrile; 3-Chloro-4-cyanobenzotrifluoride; 2-Chloro-α,α,α-trifluoro-4-methylbenzonitrile; 2-Chloro-4-trifluoromethylbenzonitrile; p-Cyanobenzotrifluoride, 2-chloro-; Benzonitrile, 2-chloro-4-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-(Trifluoromethyl)Benzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	64 - 68 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.