Description

1-Bromo-4-Chloro-5-Fluoro-2-Nitrobenzene is a high-purity, multi-substituted benzene derivative serving as a critical building block in advanced organic synthesis. Its unique halogen and nitro substitution pattern makes it an invaluable intermediate for constructing complex molecules with specific electronic and steric properties. This compound is primarily sought by R&D and production teams in the pharmaceutical and agrochemical industries for developing new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for fluorinated drug candidates targeting CNS disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and pesticides, where the halogen atoms contribute to biological activity and environmental stability.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Dye and Pigment Manufacturing: Acts as an intermediate for synthesizing complex, high-performance dyes and pigments, leveraging the nitro group for chromophore development.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) due to the presence of the bromo substituent, enabling precise molecular architecture.
• Chemical Library Development: Employed in combinatorial chemistry and high-throughput screening for generating diverse compound libraries in drug discovery programs.

Basic Information

Product Name	1-Bromo-4-Chloro-5-Fluoro-2-Nitrobenzene
CAS No.	960000-93-5
Molecular Formula	C6H2BrClFNO2
Molecular Weight	269.44 g/mol
Synonyms	4-Bromo-1-Chloro-2-Fluoro-5-Nitrobenzene; 2-Nitro-4-Bromo-1-Chloro-5-Fluorobenzene; 5-Flu-oro-2-Nitro-4-Bromo-1-Chlorobenzene; Benzene, 1-bromo-4-chloro-5-fluoro-2-nitro-; BCFNB (abbreviation); 1-Bromo-4-chloro-5-fluoro-2-nitro-benzene; 4-Bromo-1-chloro-5-fluoro-2-nitrobenzene
EINECS	Contact for details

Quality Control

Our 1-Bromo-4-Chloro-5-Fluoro-2-Nitrobenzene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and elemental analysis, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring GMP-grade intermediates and materials for regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C/59-77°F). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber-colored or stored in light-resistant packaging. Keep the container tightly sealed when not in use to prevent contamination and moisture absorption.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.